Performance of tumor growth kinetics as an imaging biomarker for response assessment in colorectal liver metastases: correlation with FDG PET
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| 024 | 7 | 0 | |a 10.1007/s00261-015-0546-1 |2 doi |
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| 245 | 0 | 0 | |a Performance of tumor growth kinetics as an imaging biomarker for response assessment in colorectal liver metastases: correlation with FDG PET |h [Elektronische Daten] |c [Adeel Seyal, Keyur Parekh, Atilla Arslanoglu, Fernanda Gonzalez-Guindalini, Sandra Tochetto, Yuri Velichko, Vahid Yaghmai] |
| 520 | 3 | |a Purpose: To correlate RECIST, volumetric criteria, and tumor growth kinetics at multidetector-computed tomography with tumor metabolic activity at FDG PET in colorectal liver metastases (CRCLM) treated with bevacizumab-based chemotherapy. Methods: Thirty-two CRCLM in 20 patients treated with bevacizumab-based chemotherapy were evaluated. Pre- and post-treatment CT scans were used to calculate reciprocal of doubling time (RDT), percentage change in the lesion's longest transaxial diameter (RECIST 1.1), and percentage change in the tumor volume. The accuracy of these parameters in predicting response based on standard uptake value analysis at FDG PET was assessed. Data were analyzed using Spearman's correlation, student's t, Mann-Whitney, Wilcoxon signed-rank, and Fisher's exact tests. Results: According to FDG PET, 24/32 (75%) lesions were categorized as responders and 8/32 (25%) lesions as nonresponders. Based on RDT, 26/32 (81.25%) lesions were classified as responders and 6/32 (18.75%) lesions as nonresponders. Response classification according to RDT and FDG PET was concordant in 30/32 (93.75%) lesions, whereas RECIST 1.1 and volumetric criteria were concordant with FDG PET for 20/32 (62.5%) and 21/32 (65.63%) lesions, respectively. A strong association was found between RDT and response based on FDG PET (odds ratio=127.4; 95% CI 5.54-2997; P<0.0001). Conclusions: Tumor growth kinetics may be an effective imaging biomarker for response evaluation in CRCLM. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Computed tomography |2 nationallicence | |
| 690 | 7 | |a Colorectal cancer |2 nationallicence | |
| 690 | 7 | |a Liver metastases |2 nationallicence | |
| 690 | 7 | |a RECIST |2 nationallicence | |
| 690 | 7 | |a Tumor growth kinetics |2 nationallicence | |
| 690 | 7 | |a WHO : World Health Organization |2 nationallicence | |
| 690 | 7 | |a RECIST : Response Evaluation Criteria in Solid Tumors |2 nationallicence | |
| 690 | 7 | |a 18F FDG : 18-Fluoro-2-deoxyglucose |2 nationallicence | |
| 690 | 7 | |a PET : Positron emission tomography |2 nationallicence | |
| 690 | 7 | |a CRCLM : Colorectal liver metastases |2 nationallicence | |
| 690 | 7 | |a MDCT : Multidetector-computed tomography |2 nationallicence | |
| 690 | 7 | |a SUV : Standard uptake value |2 nationallicence | |
| 690 | 7 | |a CR : Complete response |2 nationallicence | |
| 690 | 7 | |a PR : Partial response |2 nationallicence | |
| 690 | 7 | |a SD : Stable disease |2 nationallicence | |
| 690 | 7 | |a PD : Progressive disease |2 nationallicence | |
| 690 | 7 | |a RDT : Reciprocal of doubling time |2 nationallicence | |
| 700 | 1 | |a Seyal |D Adeel |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | |
| 700 | 1 | |a Parekh |D Keyur |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | |
| 700 | 1 | |a Arslanoglu |D Atilla |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | |
| 700 | 1 | |a Gonzalez-Guindalini |D Fernanda |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | |
| 700 | 1 | |a Tochetto |D Sandra |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | |
| 700 | 1 | |a Velichko |D Yuri |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | |
| 700 | 1 | |a Yaghmai |D Vahid |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/8(2015-10-01), 3043-3051 |x 0942-8925 |q 40:8<3043 |1 2015 |2 40 |o 261 | |
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| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Seyal |D Adeel |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Parekh |D Keyur |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Arslanoglu |D Atilla |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gonzalez-Guindalini |D Fernanda |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tochetto |D Sandra |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Velichko |D Yuri |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yaghmai |D Vahid |u Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/8(2015-10-01), 3043-3051 |x 0942-8925 |q 40:8<3043 |1 2015 |2 40 |o 261 | ||