caa a22 4500 605494738 CHVBK 20210128100527.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0546-1 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0546-1 Performance of tumor growth kinetics as an imaging biomarker for response assessment in colorectal liver metastases: correlation with FDG PET [Elektronische Daten] [Adeel Seyal, Keyur Parekh, Atilla Arslanoglu, Fernanda Gonzalez-Guindalini, Sandra Tochetto, Yuri Velichko, Vahid Yaghmai] Purpose: To correlate RECIST, volumetric criteria, and tumor growth kinetics at multidetector-computed tomography with tumor metabolic activity at FDG PET in colorectal liver metastases (CRCLM) treated with bevacizumab-based chemotherapy. Methods: Thirty-two CRCLM in 20 patients treated with bevacizumab-based chemotherapy were evaluated. Pre- and post-treatment CT scans were used to calculate reciprocal of doubling time (RDT), percentage change in the lesion's longest transaxial diameter (RECIST 1.1), and percentage change in the tumor volume. The accuracy of these parameters in predicting response based on standard uptake value analysis at FDG PET was assessed. Data were analyzed using Spearman's correlation, student's t, Mann-Whitney, Wilcoxon signed-rank, and Fisher's exact tests. Results: According to FDG PET, 24/32 (75%) lesions were categorized as responders and 8/32 (25%) lesions as nonresponders. Based on RDT, 26/32 (81.25%) lesions were classified as responders and 6/32 (18.75%) lesions as nonresponders. Response classification according to RDT and FDG PET was concordant in 30/32 (93.75%) lesions, whereas RECIST 1.1 and volumetric criteria were concordant with FDG PET for 20/32 (62.5%) and 21/32 (65.63%) lesions, respectively. A strong association was found between RDT and response based on FDG PET (odds ratio=127.4; 95% CI 5.54-2997; P<0.0001). Conclusions: Tumor growth kinetics may be an effective imaging biomarker for response evaluation in CRCLM. Springer Science+Business Media New York, 2015 Computed tomography nationallicence Colorectal cancer nationallicence Liver metastases nationallicence RECIST nationallicence Tumor growth kinetics nationallicence WHO : World Health Organization nationallicence RECIST : Response Evaluation Criteria in Solid Tumors nationallicence 18F FDG : 18-Fluoro-2-deoxyglucose nationallicence PET : Positron emission tomography nationallicence CRCLM : Colorectal liver metastases nationallicence MDCT : Multidetector-computed tomography nationallicence SUV : Standard uptake value nationallicence CR : Complete response nationallicence PR : Partial response nationallicence SD : Stable disease nationallicence PD : Progressive disease nationallicence RDT : Reciprocal of doubling time nationallicence Seyal Adeel Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut Parekh Keyur Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut Arslanoglu Atilla Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut Gonzalez-Guindalini Fernanda Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut Tochetto Sandra Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut Velichko Yuri Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut Yaghmai Vahid Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3043-3051 0942-8925 40:8<3043 2015 40 261 https://doi.org/10.1007/s00261-015-0546-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0546-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seyal Adeel Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Parekh Keyur Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Arslanoglu Atilla Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Gonzalez-Guindalini Fernanda Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Tochetto Sandra Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Velichko Yuri Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Yaghmai Vahid Department of Radiology, Northwestern Memorial Hospital, Northwestern University-Feinberg School of Medicine, 676 North Saint Clair Street Suite 800, 60611, Chicago, IL, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3043-3051 0942-8925 40:8<3043 2015 40 261