caa a22 4500 605494754 CHVBK 20210128100528.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00261-015-0525-6 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0525-6 Differentiation of deep venous thrombosis from femoral vein mixing artifact on routine abdominopelvic CT [Elektronische Daten] [Ankur Doshi, David Hoffman, Andrea Kierans, Justin Ream, Andrew Rosenkrantz] Purpose: The objective of this study is to assess the performance of qualitative and quantitative imaging features for the differentiation of deep venous thrombosis (DVT) from mixing artifact on routine portal venous phase abdominopelvic CT. Methods: This retrospective study included 40 adult patients with a femoral vein filling defect on portal venous phase CT and a Duplex ultrasound (n=36) or catheter venogram (n=4) to confirm presence or absence of DVT. Two radiologists (R1, R2) assessed the femoral veins for various qualitative and quantitative features. Results: 60% of patients were confirmed to have DVT and 40% had mixing artifact. Features with significantly greater frequency in DVT than mixing artifact (all p≤0.006) were central location (R1 90% vs. 28%; R2 96% vs. 31%), sharp margin (R1 83% vs. 28%; R2 96% vs. 31%), venous expansion (R1 48% vs. 6%, R2 56% vs. 6%), and venous wall enhancement (R1 62% vs. 0%; R2 48% vs. 0%). DVT exhibited significantly lower mean attenuation than mixing artifact (R1 42.1±20.2 vs. 57.1±23.6 HU; R2 43.6±19.4 vs. 58.8±23.4 HU, p≤0.031) and a significantly larger difference in vein diameter compared to the contralateral vein (R1 0.4±0.4 vs. 0.1±0.2cm; R2 0.3±0.4 vs. 0.0±0.1cm, p≤0.026). At multivariable analysis, central location and sharp margin were significant independent predictors of DVT for both readers (p≤0.013). Conclusion: Awareness of these qualitative and quantitative imaging features may improve radiologists' confidence for differentiating femoral vein DVT and mixing artifact on routine portal venous phase CT. However, given overlap with mixing artifact, larger studies remain warranted. Springer Science+Business Media New York, 2015 DVT nationallicence Femoral vein nationallicence Mixing artifact nationallicence Doshi Ankur Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA aut Hoffman David Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA aut Kierans Andrea Department of Radiology, New York-Presbyterian Hospital / Weill Cornell Medical Center, 525 East 68th Street, 10021, New York, NY, USA aut Ream Justin Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA aut Rosenkrantz Andrew Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3191-3195 0942-8925 40:8<3191 2015 40 261 https://doi.org/10.1007/s00261-015-0525-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0525-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Doshi Ankur Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Hoffman David Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Kierans Andrea Department of Radiology, New York-Presbyterian Hospital / Weill Cornell Medical Center, 525 East 68th Street, 10021, New York, NY, USA aut NATIONALLICENCE 700 1- Ream Justin Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Rosenkrantz Andrew Department of Radiology, NYU School of Medicine, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/8(2015-10-01), 3191-3195 0942-8925 40:8<3191 2015 40 261