caa a22 4500 605495025 CHVBK 20210128100529.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00261-015-0371-6 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0371-6 Diagnostic accuracy of F-18 FDG PET/CECT vs. CECT for detecting recurrence of periampullary carcinoma and its prognostic significance [Elektronische Daten] [Sampath Santhosh, Bhagwant Mittal, Mandeep Kang, Rakesh Kapoor, Rajesh Gupta, Surinder Rana, Anish Bhattacharya, Deepak Bhasin] Purpose: To evaluate the additive value of whole-body F-18 fluoro-deoxyglucose positron emission tomography (FDG PET) as an adjunct to contrast-enhanced computed tomography (CECT) for detecting recurrence following Whipple's resection for periampullary carcinoma and to analyze the prognostic significance of FDG PET-/CECT-based detection of recurrence. Methods: Fifty patients (34 males, 16 females; mean age: 55±11years) who underwent PET/CECT following resection of periampullary carcinoma were included. The study was duly approved by the institutional ethical committee for retrospective analysis of the data. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of FDG PET/CECT and CECT alone for detection of recurrence were calculated, and the accuracy was compared with ROC analysis. The prognostic factors for survival following recurrence were analyzed by univariate and multivariate methods. Results: PET/CECT indicated recurrence of disease in 26 (52%) patients. The overall mean survival time was 46months with an overall survival rate of 42%. The sensitivity, specificity, PPV, NPV and accuracy of PET/CECT and CECT for detection of recurrence were 96.1%, 91.6%, 92.6%, 95.6%, 94% and 76.9%, 75%, 76.9%, 75%, 76%, respectively (p=0.037). Also change in management could have been achieved in 18% of patients based on the PET/CECT results. In univariate analyses, SUVmax >7.3 was the only predictor of poor survival (p<0.05). Conclusion: PET/CECT could be used as a one-stop imaging tool for staging and prognostication of recurrent periampullary carcinoma that could result in better patient management. Springer Science+Business Media New York, 2015 Periampullary carcinoma nationallicence FDG PET/CECT nationallicence Recurrence nationallicence Survival nationallicence CECT nationallicence Santhosh Sampath Department of Nuclear medicine and PET, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Mittal Bhagwant Department of Nuclear medicine and PET, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Kang Mandeep Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Kapoor Rakesh Department of Radiotherapy, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Gupta Rajesh Department of Surgical Gasteroenterology, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Rana Surinder Department of Medical Gasteroenterology, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Bhattacharya Anish Department of Nuclear medicine and PET, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Bhasin Deepak Department of Medical Gasteroenterology, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1131-1137 0942-8925 40:5<1131 2015 40 261 https://doi.org/10.1007/s00261-015-0371-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0371-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Santhosh Sampath Department of Nuclear medicine and PET, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 700 1- Mittal Bhagwant Department of Nuclear medicine and PET, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 700 1- Kang Mandeep Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 700 1- Kapoor Rakesh Department of Radiotherapy, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 700 1- Gupta Rajesh Department of Surgical Gasteroenterology, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 700 1- Rana Surinder Department of Medical Gasteroenterology, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 700 1- Bhattacharya Anish Department of Nuclear medicine and PET, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 700 1- Bhasin Deepak Department of Medical Gasteroenterology, Postgraduate Institute of Medical Education and Research, 160 012, Chandigarh, India aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1131-1137 0942-8925 40:5<1131 2015 40 261