caa a22 4500 605495033 CHVBK 20210128100529.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00261-015-0403-2 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0403-2 Longitudinal diffusion-weighted imaging changes in children with small bowel Crohn's disease: preliminary experience [Elektronische Daten] [Daniel Rosenbaum, Melissa Rose, Aliza Solomon, Ashley Giambrone, Arzu Kovanlikaya] Purpose: Crohn's disease has been associated with restricted diffusion in diseased small bowel segments on diffusion-weighted imaging (DWI). However, data addressing longitudinal changes in DWI findings and their potential clinical ramifications in the pediatric population are lacking. The purpose of this study was to follow DWI changes in diseased small bowel segments between serial magnetic resonance enterography (MRE) examinations, and to correlate these changes with other imaging parameters and clinical status. Methods: This retrospective study evaluated patients less than 21years of age undergoing serial MRE examinations including DWI for Crohn's disease involving the small bowel. All patients carried a diagnosis of Crohn's disease established by pathology or corroborative clinical and imaging findings. Longitudinal changes in mean apparent diffusion coefficient (ADC) values within the wall of affected small bowel lesions were recorded and normalized to both unaffected bowel and skeletal muscle. ADC changes were correlated with qualitative imaging phenotype, as reflected by a defined set of non-DWI imaging parameters, as well as with clinical disease activity. Results: Seventeen lesions were evaluated longitudinally, distributed among 13 patients (9 boys and 4 girls, mean age at baseline 16.6years), each of whom had two sequential MRE examinations. Lesions demonstrating a fibrostenotic imaging phenotype at follow-up MRE had a significantly lower change in mean ADC value between examinations than lesions that did not have a fibrostenotic imaging phenotype (p=0.0005), an effect that persisted when ADC values were normalized to unaffected bowel and skeletal muscle. Across all studies, lesions with a fibrostenotic imaging phenotype had lower ADC values than those with an inflammatory imaging phenotype, which were in turn lower than those with a normal imaging phenotype (p=0.0001). Conclusion: Patterns of longitudinal DWI changes in Crohn's disease may differ among small bowel lesions depending upon their specific natural histories. These findings may assist in the evaluation of the ADC value as a potential imaging surrogate when evaluating lesion status, particularly as it pertains to relative contributions of inflammation and fibrosis. Springer Science+Business Media New York, 2015 Crohn's disease nationallicence Inflammatory bowel disease nationallicence MR enterography nationallicence Diffusion-weighted imaging nationallicence Rosenbaum Daniel Department of Radiology, Weill Cornell Medical College/NewYork-Presbyterian Hospital, 525 E. 68th St., 10065, New York, NY, USA aut Rose Melissa Department of Pediatric Gastroenterology and Nutrition, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA aut Solomon Aliza Department of Pediatric Gastroenterology and Nutrition, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA aut Giambrone Ashley Department of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY, USA aut Kovanlikaya Arzu Department of Radiology, Weill Cornell Medical College/NewYork-Presbyterian Hospital, 525 E. 68th St., 10065, New York, NY, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1075-1080 0942-8925 40:5<1075 2015 40 261 https://doi.org/10.1007/s00261-015-0403-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0403-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosenbaum Daniel Department of Radiology, Weill Cornell Medical College/NewYork-Presbyterian Hospital, 525 E. 68th St., 10065, New York, NY, USA aut NATIONALLICENCE 700 1- Rose Melissa Department of Pediatric Gastroenterology and Nutrition, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA aut NATIONALLICENCE 700 1- Solomon Aliza Department of Pediatric Gastroenterology and Nutrition, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, NY, USA aut NATIONALLICENCE 700 1- Giambrone Ashley Department of Biostatistics and Epidemiology, Weill Cornell Medical College, New York, NY, USA aut NATIONALLICENCE 700 1- Kovanlikaya Arzu Department of Radiology, Weill Cornell Medical College/NewYork-Presbyterian Hospital, 525 E. 68th St., 10065, New York, NY, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1075-1080 0942-8925 40:5<1075 2015 40 261