Multireader evaluation of lesion conspicuity in small pancreatic adenocarcinomas: complimentary value of iodine material density and low keV simulated monoenergetic images using multiphasic rapidkVp-switching dual energy CT
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0274-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0274-y | ||
| 245 | 0 | 0 | |a Multireader evaluation of lesion conspicuity in small pancreatic adenocarcinomas: complimentary value of iodine material density and low keV simulated monoenergetic images using multiphasic rapidkVp-switching dual energy CT |h [Elektronische Daten] |c [Michelle McNamara, Mark Little, Lauren Alexander, L. Van Carroll, T. Mark Beasley, Desiree Morgan] |
| 520 | 3 | |a Objective: Perform multireader analysis of objective and subjective lesion conspicuity for small pancreatic adenocarcinomas using rapid switching dual energy CT (rsDECT). Materials and methods: With IRB approval, 51 abdominal multiphasic rsDECT scans in 46 subjects with small (<3cm) pancreatic adenocarcinomas were retrospectively reviewed by three independent readers for objective and subjective lesion conspicuity. Measured variables during individual, blinded interpretive sessions of separate low (52)keV, PACS-equivalent (70)keV, and iodine material density (MD) image sets included Hounsfield units (HU) and mg/cc iodine for tumor, nontumoral pancreas, and subcutaneous fat. Objective measures included absolute lesion contrast (LC) and contrast to noise ratios (CNR). Subjective measures included image quality, lesion conspicuity, and reader confidence. Reader agreement was measured with kappa statistic; correlation with truth by Pearson coefficient, CNR with repeated mANOVA; subjective quality measures utilized Tukey-Cramer corrections for multiple testing, p<0.05 considered significant. Results: Demographics: 26 F, 20M, mean age 68years, weight 75kg, tumor size of 2.3cm. LC was highest on 52keV images for all three readers (mean 90.1 HU). Mean CNR for iodine MD images (4.87) was significantly higher than 52keV (4.13) or 70keV (3.9). Very high to near-perfect kappa values were observed for all individual measured objective variables but were best for 52keV images (52keV 0.89-0.95, 70keV 0.76-0.83, iodine 0.87-0.92). 70keV images scored best for subjective image quality; iodine MD images scored best for lesion conspicuity and reader confidence. Conclusion: We observed very high reader agreement for independent objective rsDECT image variables and subjective rsDECT image scores in patients with small pancreatic adenocarcinomas. Maximal objective tumor to nontumoral LC was depicted on 52keV and highest CNR on iodine MD images; readers scored the iodine MD images best for lesion conspicuity and confidence. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Dual energy CT |2 nationallicence | |
| 690 | 7 | |a Pancreas |2 nationallicence | |
| 690 | 7 | |a Ductal adenocarcinoma |2 nationallicence | |
| 690 | 7 | |a Multireader agreement |2 nationallicence | |
| 700 | 1 | |a McNamara |D Michelle |u Department of Radiology, School of Medicine, University of Alabama at Birmingham, JTN452, 619 South 19th Street, 35249, Birmingham, AL, USA |4 aut | |
| 700 | 1 | |a Little |D Mark |u Department of Radiology, School of Medicine, University of Alabama at Birmingham, JTN452, 619 South 19th Street, 35249, Birmingham, AL, USA |4 aut | |
| 700 | 1 | |a Alexander |D Lauren |u Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA |4 aut | |
| 700 | 1 | |a Van Carroll |D L. |u University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA |4 aut | |
| 700 | 1 | |a Mark Beasley |D T. |u Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA |4 aut | |
| 700 | 1 | |a Morgan |D Desiree |u Department of Radiology, School of Medicine, University of Alabama at Birmingham, JTN452, 619 South 19th Street, 35249, Birmingham, AL, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/5(2015-06-01), 1230-1240 |x 0942-8925 |q 40:5<1230 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0274-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0274-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a McNamara |D Michelle |u Department of Radiology, School of Medicine, University of Alabama at Birmingham, JTN452, 619 South 19th Street, 35249, Birmingham, AL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Little |D Mark |u Department of Radiology, School of Medicine, University of Alabama at Birmingham, JTN452, 619 South 19th Street, 35249, Birmingham, AL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Alexander |D Lauren |u Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Van Carroll |D L. |u University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mark Beasley |D T. |u Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Morgan |D Desiree |u Department of Radiology, School of Medicine, University of Alabama at Birmingham, JTN452, 619 South 19th Street, 35249, Birmingham, AL, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/5(2015-06-01), 1230-1240 |x 0942-8925 |q 40:5<1230 |1 2015 |2 40 |o 261 | ||