caa a22 4500 605495106 CHVBK 20210128100529.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00261-014-0277-8 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0277-8 Comparison of 18F-FDG PET/CT methods of analysis for predicting response to neoadjuvant chemoradiation therapy in patients with locally advanced low rectal cancer [Elektronische Daten] [Corinna Altini, Artor Niccoli Asabella, Raffaele De Luca, Margherita Fanelli, Cosimo Caliandro, Natale Quartuccio, Domenico Rubini, Angelina Cistaro, Severino Montemurro, Giuseppe Rubini] Purpose: The aim of this study was to prospectively investigate the predictive value of 18F-FDG PET/CT semiquantitative parameters for locally advanced low rectal cancer (LARC) treated by neoadjuvant chemoradiation therapy (nCRT). Methods: 68 patients with LARC had 18F-FDG PET/CT scans twice (baseline and 5-6weeks post-nCRT). All patients underwent surgery with preservation of the sphincter 8weeks later. 18F-FDG PET/CT analysis was performed by visual response assessment (VRA) and semiquantitative parameters: SUVmaxbaseline, SUVmeanbaseline, MTVbaseline, TLGbaseline, SUVmaxpost-nCRT, SUVmeanpost-nCRT, MTVpost-nCRT, TLGpost-nCRT; ΔSUVmax and mean and Response indexes (RImax% and RImean%). Assessment of nCRT tumor response was performed according to the Mandard's Tumor Regression Grade (TRG) and (y)pTNM staging on the surgical specimens. Concordances of VRA with TRG, and with (y)pTNM criteria were evaluated by Cohen's K. Results were compared by t student test for unpaired groups. ROC curve analysis was performed. Results: VRA analysis of post-nCRT 18F-FDG PET/CT scan for the (y)pTNM outcome showed sensitivity, specificity, accuracy, PPV, and NPV of 87.5%, 66.7%, 83.8%, 92.5%, and 53.3%, respectively. Concordances of VRA with TRG and with (y)pTNM were moderate. For the outcome variable TRG, the statistical difference between responders and non-responders was significant for SUVmaxpost-nCRT and RImean%; for the outcome variable (y)pTNM, there was a significant difference for MTVbaseline, SUVmaxpost-nCRT, SUVmeanpost-nCRT, MTVpost-nCRT, RImax%, and RImean%. ROC analysis showed better AUCs: for the outcome variable TRG for SUVmaxpost-nCRT, SUVmeanpost-nCRT, and RImean%; for the outcome variable (y)pTNM for MTVbaseline, SUVmaxpost-nCRT, SUVmeanpost-nCRT, MTVpost-nCRT, RImax%, and RImean%. No significant differences among parameters were found. Conclusions: Qualitative and semiquantitative evaluations for 18F-FDG PET/CT are the optimal approach; a valid parameter for response prediction has still to be established. Springer Science+Business Media New York, 2014 18F-FDG PET/CT nationallicence nCRT nationallicence LARC nationallicence Qualitative evaluation nationallicence Semiquantitative analysis nationallicence Altini Corinna Nuclear Medicine Unit, D.I.M., University of Bari "Aldo Moro”, Bari, Italy aut Niccoli Asabella Artor Nuclear Medicine Unit, D.I.M., University of Bari "Aldo Moro”, Bari, Italy aut De Luca Raffaele Department of Surgical Oncology, Istituto Tumori G. Paolo II, IRCCS, Bari, Italy aut Fanelli Margherita Nuclear Medicine Unit, D.I.M., University of Bari "Aldo Moro”, Bari, Italy aut Caliandro Cosimo Department of Surgical Oncology, Istituto Tumori G. Paolo II, IRCCS, Bari, Italy aut Quartuccio Natale Nuclear Medicine Unit, Department of Biomedical Sciences and of Morphological and Functional Images, University of Messina, Messina, Italy aut Rubini Domenico Nuclear Medicine Unit, D.I.M., University of Bari "Aldo Moro”, Bari, Italy aut Cistaro Angelina Positron Emission Tomography Centre, IRMET S.p.A., Euromedic, Turin, Italy aut Montemurro Severino Department of Surgical Oncology, Istituto Tumori G. Paolo II, IRCCS, Bari, Italy aut Rubini Giuseppe Nuclear Medicine Unit, D.I.M., University of Bari "Aldo Moro”, Bari, Italy aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1190-1202 0942-8925 40:5<1190 2015 40 261 https://doi.org/10.1007/s00261-014-0277-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0277-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Altini Corinna Nuclear Medicine Unit, D.I.M., University of Bari "Aldo Moro”, Bari, Italy aut NATIONALLICENCE 700 1- Niccoli Asabella Artor Nuclear Medicine Unit, D.I.M., University of Bari "Aldo Moro”, Bari, Italy aut NATIONALLICENCE 700 1- De Luca Raffaele Department of Surgical Oncology, Istituto Tumori G. Paolo II, IRCCS, Bari, Italy aut NATIONALLICENCE 700 1- Fanelli Margherita Nuclear Medicine Unit, D.I.M., University of Bari "Aldo Moro”, Bari, Italy aut NATIONALLICENCE 700 1- Caliandro Cosimo Department of Surgical Oncology, Istituto Tumori G. Paolo II, IRCCS, Bari, Italy aut NATIONALLICENCE 700 1- Quartuccio Natale Nuclear Medicine Unit, Department of Biomedical Sciences and of Morphological and Functional Images, University of Messina, Messina, Italy aut NATIONALLICENCE 700 1- Rubini Domenico Nuclear Medicine Unit, D.I.M., University of Bari "Aldo Moro”, Bari, Italy aut NATIONALLICENCE 700 1- Cistaro Angelina Positron Emission Tomography Centre, IRMET S.p.A., Euromedic, Turin, Italy aut NATIONALLICENCE 700 1- Montemurro Severino Department of Surgical Oncology, Istituto Tumori G. Paolo II, IRCCS, Bari, Italy aut NATIONALLICENCE 700 1- Rubini Giuseppe Nuclear Medicine Unit, D.I.M., University of Bari "Aldo Moro”, Bari, Italy aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1190-1202 0942-8925 40:5<1190 2015 40 261