caa a22 4500 605495157 CHVBK 20210128100530.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00261-014-0272-0 doi (NATIONALLICENCE)springer-10.1007/s00261-014-0272-0 CT predictors of overall survival at initial diagnosis in patients with stage IV colorectal cancer [Elektronische Daten] [Michael Rosenthal, Kyung Kim, Charles Fuchs, Jeffrey Meyerhardt, Nikhil Ramaiya] Purpose: We investigated whether the initial CT distribution of metastatic disease is predictive of overall survival in patients with stage IV colorectal cancer. Materials and methods: A retrospective study of 65 patients (37 males, 28 females, mean age 56, range 28-88years) with stage IV colorectal cancer was derived from an institutional database. Inclusion criteria required KRAS mutation testing and pretreatment CT examinations to be available (65 abdomen/pelvis, 63 chest). Disease burden was jointly characterized by two radiologists in consensus. Median follow-up was 39months (range 8-115months). Survival was assessed using Cox proportional hazards models. Results: Univariate analysis showed that stratified site(s) of measurable disease and counts of measurable lesions ≥1cm in the liver, peritoneum, and retroperitoneum were statistically significant risk factors for overall mortality [univariate HR 8.2 (CI 2.7-25.4) for isolated peritoneal disease, HR 1.11 per 5 lesions (CI 1.05-1.17) for liver lesions, HR 1.15 per lesion (CI 1.05-1.26) for peritoneal lesions, and HR 1.11 (CI 1.03-1.19) for retroperitoneal lymph nodes ≥1cm in short axis]. The stratified site(s) of disease and counts of measurable liver lesions remained significant in the multivariate model (p<0.0001 for isolated peritoneal disease and count of liver lesions). Thoracic metastases were not statistically significant predictors of overall mortality in this cohort. Conclusion: This study identified site(s) of measurable metastasis and counts of measurable liver lesions as independent predictors of overall survival. These findings may have value for future prognostic assessments once validated in a larger, independent, and potentially prospective cohort. Springer Science+Business Media New York, 2014 Colorectal cancer nationallicence Diagnostic imaging nationallicence Patient outcome assessment nationallicence Prognosis nationallicence Rosenthal Michael Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02115, Boston, MA, USA aut Kim Kyung Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02115, Boston, MA, USA aut Fuchs Charles Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02115, Boston, MA, USA aut Meyerhardt Jeffrey Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02115, Boston, MA, USA aut Ramaiya Nikhil Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02115, Boston, MA, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1170-1176 0942-8925 40:5<1170 2015 40 261 https://doi.org/10.1007/s00261-014-0272-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0272-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rosenthal Michael Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Kim Kyung Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Fuchs Charles Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Meyerhardt Jeffrey Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Ramaiya Nikhil Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1170-1176 0942-8925 40:5<1170 2015 40 261