caa a22 4500 605495211 CHVBK 20210128100530.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00261-015-0367-2 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0367-2 NSAID enteropathy: appearance at CT and MR enterography in the age of multi-modality imaging and treatment [Elektronische Daten] [Judson Frye, Stephanie Hansel, Steven Dolan, Jeff Fidler, Louis Song, John Barlow, Tom Smyrk, Kristina Flicek, Amy Hara, David Bruining, Joel Fletcher] CT and MR enterography and capsule endoscopy are increasingly used as routine diagnostic tests for patients with potential small bowel disorders and obscure gastrointestinal bleeding. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used drugs that disrupt prostaglandin synthesis and result in a variety of localized complications within the small bowel ranging from ulcer formation to characteristic circumferential strictures, or diaphragms. NSAID enteropathy encompasses this spectrum of acute and chronic inflammatory sequelae, and is associated with typical findings at capsule endoscopy and surgery. Herein we review the typical clinical presentation of NSAID enteropathy, in addition to its endoscopic appearances, focusing on imaging findings at cross-sectional enterography. Multiple, short-segment strictures are the hallmarks of imaging diagnosis. Strictures may have minimal hyperenhancement or wall thickening, but these findings are typically symmetric and circumferential with respect to the bowel lumen. Multifocal Crohn's strictures, and occasionally radiation-induced strictures or adhesions, will mimic NSAID diaphragms. Multi-phase or multi-sequence imaging at CT and MR enterography increase diagnostic confidence in stricture presence. Strategies for subsequent workup and therapy after enterography are also discussed. Given the frequent use of NSAIDs and typical appearance of these strictures, knowledge of characteristic imaging findings can be particularly useful when evaluating patients with anemia and recurrent small bowel obstruction. Springer Science+Business Media New York, 2015 Small bowel nationallicence CT enterography nationallicence Capsule endoscopy nationallicence NSAID enteropathy nationallicence Frye Judson Department of Radiology, Mayo Clinic Health System, La Crosse, WI, USA aut Hansel Stephanie Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA aut Dolan Steven Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA aut Fidler Jeff Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Song Louis Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA aut Barlow John Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Smyrk Tom Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA aut Flicek Kristina Department of Radiology, University of Arizona, Tucson, AZ, USA aut Hara Amy Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA aut Bruining David Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA aut Fletcher Joel Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1011-1025 0942-8925 40:5<1011 2015 40 261 https://doi.org/10.1007/s00261-015-0367-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0367-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Frye Judson Department of Radiology, Mayo Clinic Health System, La Crosse, WI, USA aut NATIONALLICENCE 700 1- Hansel Stephanie Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Dolan Steven Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Fidler Jeff Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Song Louis Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Barlow John Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Smyrk Tom Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Flicek Kristina Department of Radiology, University of Arizona, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Hara Amy Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Bruining David Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Fletcher Joel Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1011-1025 0942-8925 40:5<1011 2015 40 261