caa a22 4500 605495270 CHVBK 20210128100530.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00261-015-0384-1 doi (NATIONALLICENCE)springer-10.1007/s00261-015-0384-1 Observer performance for adaptive, image-based denoising and filtered back projection compared to scanner-based iterative reconstruction for lower dose CT enterography [Elektronische Daten] [Joel Fletcher, Amy Hara, Jeff Fidler, Alvin Silva, John Barlow, Rickey Carter, Adam Bartley, Maria Shiung, David Holmes III, Nicolas Weber, David Bruining, Lifeng Yu, Cynthia McCollough] Purpose: The purpose of this study was to compare observer performance for detection of intestinal inflammation for low-dose CT enterography (LD-CTE) using scanner-based iterative reconstruction (IR) vs. vendor-independent, adaptive image-based noise reduction (ANLM) or filtered back projection (FBP). Methods: Sixty-two LD-CTE exams were performed. LD-CTE images were reconstructed using IR, ANLM, and FBP. Three readers, blinded to image type, marked intestinal inflammation directly on patient images using a specialized workstation over three sessions, interpreting one image type/patient/session. Reference standard was created by a gastroenterologist and radiologist, who reviewed all available data including dismissal Gastroenterology records, and who marked all inflamed bowel segments on the same workstation. Reader and reference localizations were then compared. Non-inferiority was tested using Jackknife free-response ROC (JAFROC) figures of merit (FOM) for ANLM and FBP compared to IR. Patient-level analyses for the presence or absence of inflammation were also conducted. Results: There were 46 inflamed bowel segments in 24/62 patients (CTDIvol interquartile range 6.9-10.1mGy). JAFROC FOM for ANLM and FBP were 0.84 (95% CI 0.75-0.92) and 0.84 (95% CI 0.75-0.92), and were statistically non-inferior to IR (FOM 0.84; 95% CI 0.76-0.93). Patient-level pooled confidence intervals for sensitivity widely overlapped, as did specificities. Image quality was rated as better with IR and AMLM compared to FBP (p<0.0001), with no difference in reading times (p=0.89). Conclusions: Vendor-independent adaptive image-based noise reduction and FBP provided observer performance that was non-inferior to scanner-based IR methods. Adaptive image-based noise reduction maintained or improved upon image quality ratings compared to FBP when performing CTE at lower dose levels. Springer Science+Business Media New York, 2015 Crohn's disease nationallicence Radiation dose nationallicence CT nationallicence Iterative reconstruction nationallicence Fletcher Joel Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Hara Amy Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA aut Fidler Jeff Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Silva Alvin Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA aut Barlow John Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Carter Rickey Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA aut Bartley Adam Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA aut Shiung Maria Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Holmes III David Department of Biomedical Imaging Resources, Mayo Clinic, Rochester, MN, USA aut Weber Nicolas Department of Gastroenterology, Mayo Clinic, Rochester, MN, USA aut Bruining David Department of Gastroenterology, Mayo Clinic, Rochester, MN, USA aut Yu Lifeng Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut McCollough Cynthia Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1050-1059 0942-8925 40:5<1050 2015 40 261 https://doi.org/10.1007/s00261-015-0384-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-015-0384-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fletcher Joel Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Hara Amy Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Fidler Jeff Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Silva Alvin Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA aut NATIONALLICENCE 700 1- Barlow John Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Carter Rickey Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Bartley Adam Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Shiung Maria Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Holmes III David Department of Biomedical Imaging Resources, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Weber Nicolas Department of Gastroenterology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Bruining David Department of Gastroenterology, Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Yu Lifeng Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- McCollough Cynthia Department of Radiology, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1050-1059 0942-8925 40:5<1050 2015 40 261