caa a22 4500 605495300 CHVBK 20210128100530.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00261-014-0283-x doi (NATIONALLICENCE)springer-10.1007/s00261-014-0283-x Detection of liver metastases in patients with adenocarcinomas of the gastrointestinal tract: comparison of 18F-FDG PET/CT and MR imaging [Elektronische Daten] [Christian Maegerlein, Alexander Fingerle, Michael Souvatzoglou, Ernst Rummeny, Konstantin Holzapfel] Purpose: Aim of our study was to compare the diagnostic performance of 18F-FDG PET/CT and MR imaging (MRI) in the detection of liver metastases in patients with adenocarcinomas of the gastrointestinal tract. Methods: A total of 49 patients with adenocarcinomas of the gastrointestinal tract who had undergone 18F-FDG PET/CT and MRI of the liver were included in this study. The MRI protocol included diffusion-weighted imaging and dynamic contrast-enhanced MR imaging after intravenous injection of Gd-DTPA. PET and MR images were analyzed by two experienced radiologists. Imaging results were correlated with histopathological findings or imaging follow-up as available. Sensitivities of both modalities were compared using McNemar Test. Receiver operating characteristic (ROC) curves were calculated to determine the diagnostic performance in correctly identifying liver metastases. Results: A total of 151 metastases were confirmed. For lesion detection, MRI was significantly superior to 18F-FDG PET/CT. Sensitivity of MRI in detecting metastases was 86.8% for Reader 1 (R1) and 87.4% for Reader 2 (R2), of PET/CT 66.2% for R1 and 68.2% for R2. Regarding only metastases with diameters of 10mm or less, sensitivities of MRI were 66.7% for R1 and 75.0% for R2, and were significantly higher than those of PET/CT (17.9% for R1 and 20.5% for R2). ROC analysis showed superiority for lesion classification of MRI as compared to 18F-FDG PET/CT. Conclusion: MRI is significantly superior to 18F-FDG PET/CT in the detection and classification of liver metastases in patients with adenocarcinomas of the gastrointestinal tract, especially in the detection of small metastases. Springer Science+Business Media New York, 2014 18F-FDG PET/CT nationallicence Magnetic resonance imaging nationallicence Diffusion-weighted MR imaging (DWI) nationallicence Adenocarcinomas of the gastrointestinal tract nationallicence Liver metastases nationallicence Maegerlein Christian Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany aut Fingerle Alexander Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany aut Souvatzoglou Michael Department of Nuclear Medicine, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany aut Rummeny Ernst Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany aut Holzapfel Konstantin Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1213-1222 0942-8925 40:5<1213 2015 40 261 https://doi.org/10.1007/s00261-014-0283-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0283-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maegerlein Christian Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany aut NATIONALLICENCE 700 1- Fingerle Alexander Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany aut NATIONALLICENCE 700 1- Souvatzoglou Michael Department of Nuclear Medicine, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany aut NATIONALLICENCE 700 1- Rummeny Ernst Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany aut NATIONALLICENCE 700 1- Holzapfel Konstantin Department of Radiology, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, 81675, Munich, Germany aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/5(2015-06-01), 1213-1222 0942-8925 40:5<1213 2015 40 261