caa a22 4500 605495378 CHVBK 20210128100531.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00261-014-0222-x doi (NATIONALLICENCE)springer-10.1007/s00261-014-0222-x The role of pure iterative reconstruction in conventional dose CT enterography [Elektronische Daten] [Kevin Murphy, L. Crush, P. McLaughlin, Hilary O'Sullivan, Maria Twomey, Sylvia Lynch, J. Bye, Sean McSweeney, Owen O'Connor, F. Shanahan, Michael Maher] Purpose: Pure iterative reconstruction (Pure IR) has been proposed as a solution to improve diagnostic quality of low dose CT images. We assess the performance of model based iterative reconstruction (MBIR) in improving conventional dose CT enterography (CTE) images. Methods: 43 Crohn's patients (27 female) (38.5±12.98years) referred for CTE were included. Images were reconstructed with pure IR (MBIR, General Electric Healthcare) in addition to standard department protocol (reconstructed with hybrid iterative reconstruction (Hybrid IR) [60% filtered back projection/40% adaptive statistical IR (General Electric Healthcare)]. Image quality was assessed objectively and subjectively at 6 anatomical levels. Clinical interpretation was undertaken in consensus by 2 blinded radiologists along with 2 non-blinded readers (‘gold standard'). Results were analyzed using Statistical Package for Social Scientists. Results: Mean effective radiation dose was 6.05±2.84mSv (size specific dose estimates 9.25±2.9mGy). Objective and subjective assessment yielded 6106 data points. Pure IR images significantly outperformed those using standard reconstruction techniques across all subjective (p<0.001 for all comparisons) (noise, contrast resolution, spatial resolution, streak artifact, axial diagnostic acceptability, coronal diagnostic acceptability) and objective (p<0.004) (noise, signal-to-noise ratio) parameters. Clinical reads of the pure IR images agreed more closely with the gold standard reads than the hybrid IR image reads in terms of overall Crohn's activity grade (κ=0.630, 0.308) and detection of acute complications (κ=1.0, 0.896). Results were comparable for bowel wall disease severity assessment (κ=0.523, 0.593). Conclusions: Pure IR considerably improves image quality of conventional dose CTE images and therefore its use should be expanded beyond low dose protocols to improving image quality at conventional dose CT imaging. Springer Science+Business Media New York, 2014 Iterative reconstruction nationallicence Pure iterative reconstruction nationallicence Model based iterative reconstruction nationallicence Hybrid iterative reconstruction nationallicence Computed tomography nationallicence Crohn's disease nationallicence Murphy Kevin Department of Radiology, University College Cork, Cork, Ireland aut Crush L. Department of Radiology, University College Cork, Cork, Ireland aut McLaughlin P. Department of Emergency and Trauma Radiology, Vancouver General Hospital, Vancouver, BC, Canada aut O'Sullivan Hilary Department of Radiology, University College Cork, Cork, Ireland aut Twomey Maria Department of Radiology, Cork University Hospital, Cork, Ireland aut Lynch Sylvia Department of Radiology, Cork University Hospital, Cork, Ireland aut Bye J. GE Healthcare UK - Technologies, Hertfordshire, UK aut McSweeney Sean Department of Radiology, Cork University Hospital, Cork, Ireland aut O'Connor Owen Department of Radiology, University College Cork, Cork, Ireland aut Shanahan F. Department of Medicine, University College Cork, Cork, Ireland aut Maher Michael Department of Radiology, University College Cork, Cork, Ireland aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/2(2015-02-01), 251-257 0942-8925 40:2<251 2015 40 261 https://doi.org/10.1007/s00261-014-0222-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0222-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Murphy Kevin Department of Radiology, University College Cork, Cork, Ireland aut NATIONALLICENCE 700 1- Crush L. Department of Radiology, University College Cork, Cork, Ireland aut NATIONALLICENCE 700 1- McLaughlin P. Department of Emergency and Trauma Radiology, Vancouver General Hospital, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- O'Sullivan Hilary Department of Radiology, University College Cork, Cork, Ireland aut NATIONALLICENCE 700 1- Twomey Maria Department of Radiology, Cork University Hospital, Cork, Ireland aut NATIONALLICENCE 700 1- Lynch Sylvia Department of Radiology, Cork University Hospital, Cork, Ireland aut NATIONALLICENCE 700 1- Bye J. GE Healthcare UK - Technologies, Hertfordshire, UK aut NATIONALLICENCE 700 1- McSweeney Sean Department of Radiology, Cork University Hospital, Cork, Ireland aut NATIONALLICENCE 700 1- O'Connor Owen Department of Radiology, University College Cork, Cork, Ireland aut NATIONALLICENCE 700 1- Shanahan F. Department of Medicine, University College Cork, Cork, Ireland aut NATIONALLICENCE 700 1- Maher Michael Department of Radiology, University College Cork, Cork, Ireland aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/2(2015-02-01), 251-257 0942-8925 40:2<251 2015 40 261