caa a22 4500 605495424 CHVBK 20210128100531.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00261-014-0214-x doi (NATIONALLICENCE)springer-10.1007/s00261-014-0214-x Navigated three-dimensional T1-weighted gradient-echo sequence for gadoxetic acid liver magnetic resonance imaging in patients with limited breath-holding capacity [Elektronische Daten] [Jeong Yoon, Jeong Lee, Eun Lee, Jeehyun Baek, Sangwoo Lee, Yuji Iwadate, Joon Han, Byung Choi] Purpose: To determine whether a navigator-gated three-dimensional T1-weighted gradient-echo sequence (T1W-GRE, navigated LAVA) can improve diagnostic performance for the detection of focal liver lesions (FLLs) compared to standard breath-hold (BH) T1W-GRE breath-hold LAVA (BH-LAVA) during the hepatobiliary phase (HBP) of gadoxetic acid liver magnetic resonance imaging (MRI) in patients with limited breath-holding capacity. Materials and methods: This retrospective study was approved by our institutional review board and the requirement for informed consent was waived. We included 372 patients who underwent liver MRI including both navigated LAVA and BH-LAVA sequences. Overall image quality of the two HBP image sets was compared. In patients with limited breath-holding capacity, diagnostic performances in detecting FLLs on the two HBP images were compared using jackknife-alternative free-response receiver-operating characteristic (JAFROC) analysis by two reviewers. Results: There were 13 cases (13/372; 3.5%) of image acquisition failure using the navigated LAVA sequence due to severe irregular breathing, and 50 of 359 patients had limited breath-holding capacity. In these patients, overall image quality of navigated LAVA (2.78±0.95) was significantly better than that of BH-LAVA (2.42±0.81, P<0.005), and both readers showed significantly higher JAFROC figure-of-merit values with navigated LAVA compared to BH-LAVA (0.94 and 0.86 in reviewer 1, respectively; 0.89 and 0.83 in reviewer 2, respectively, P<0.005). Overall image quality of navigated LAVA was also better than that of BH-LAVA in patients with sufficient breath-holding capacity (n=309, 3.96±0.88, 3.81±0.66, respectively, P<0.001). Conclusion: The navigated LAVA sequence could provide better image quality and diagnostic performance in detecting FLLs than BH-LAVA in patients with limited breath-holding capacity during HBP of gadoxetic acid MRI. Springer Science+Business Media New York, 2014 Magnetic resonance imaging nationallicence Hepatobiliary phase nationallicence Respiratory-gated imaging nationallicence Gd-EOB-DTPA nationallicence Gadoxetic acid nationallicence Yoon Jeong Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Lee Jeong Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Lee Eun Department of Radiology, National Cancer Center, Goyang-si, Gyeonggi-do, Korea aut Baek Jeehyun Human Medical Imaging & Intervention Center, Seoul, Korea aut Lee Sangwoo Global Applied Science Laboratory, GE Healthcare, Seoul, Korea aut Iwadate Yuji Global Applied Science Laboratory, GE Healthcare, Hino, Tokyo, Japan aut Han Joon Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Choi Byung Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut Abdominal Imaging Springer US; http://www.springer-ny.com 40/2(2015-02-01), 278-288 0942-8925 40:2<278 2015 40 261 https://doi.org/10.1007/s00261-014-0214-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00261-014-0214-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoon Jeong Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jeong Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Eun Department of Radiology, National Cancer Center, Goyang-si, Gyeonggi-do, Korea aut NATIONALLICENCE 700 1- Baek Jeehyun Human Medical Imaging & Intervention Center, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Sangwoo Global Applied Science Laboratory, GE Healthcare, Seoul, Korea aut NATIONALLICENCE 700 1- Iwadate Yuji Global Applied Science Laboratory, GE Healthcare, Hino, Tokyo, Japan aut NATIONALLICENCE 700 1- Han Joon Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Byung Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 110-744, Seoul, Korea aut NATIONALLICENCE 773 0- Abdominal Imaging Springer US; http://www.springer-ny.com 40/2(2015-02-01), 278-288 0942-8925 40:2<278 2015 40 261