Whole-lesion diffusion metrics for assessment of bladder cancer aggressiveness
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0213-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0213-y | ||
| 245 | 0 | 0 | |a Whole-lesion diffusion metrics for assessment of bladder cancer aggressiveness |h [Elektronische Daten] |c [Andrew Rosenkrantz, Chika Obele, Henry Rusinek, Arjun Balar, William Huang, Fang-Ming Deng, Justin Ream] |
| 520 | 3 | |a Purpose: To explore associations of whole-lesion histogram diffusion metrics with pathologic findings and subsequent metastatic disease in bladder cancer patients undergoing radical cystectomy. Methods: Twenty-three bladder cancer patients (21M, 2F; mean 70±11years) underwent MRI before cystectomy. A volume-of-interest was placed on all slices on the ADC map encompassing each lesion. Whole-lesion mean, kurtosis, and skewness of ADC were calculated and compared with T stage and pelvic nodal status at cystectomy and with subsequent metastasis in 20/25 patients with available follow-up. Results: At cystectomy, 39% (9/23) were stage T2, 61% (14/23) ≥T3, and 28% (5/23) exhibited positive nodes; 35% (7/20) developed later metastases. Mean ADC was significantly lower in stage ≥T3 than in lower stage tumors (1.20±0.36×10−3 vs. 1.55±0.36×10−3mm2/s; p=0.044), but showed no association with nodal or metastatic disease (p=0.362-0.709). Kurtosis was significantly lower in tumors with, compared to without, nodal disease (−0.05±0.29 vs. 0.91±1.16; p=0.037), and showed a non-significant decrease in tumors with, compared to without, later metastases (0.23±0.63 vs. 0.83±0.89; p=0.088). Kurtosis was not associated with T stage (p=0.811), and skew was not associated with any outcome (p=0.516-0.643). Mean ADC achieved highest AUC for identification of stage ≥T3 (AUC=0.754 vs. 0.516-0.643 for other metrics). Kurtosis achieved highest AUC for nodal disease (AUC=0.811 vs. 0.522-0.556 for other metrics) and metastases (AUC=0.736 vs. 0.516-0.626 for other metrics). Only difference in AUC between skewness and kurtosis for nodal disease was significant (p=0.031). Conclusion: While requiring larger studies, kurtosis has potential to complement mean ADC in bladder cancer prognosis using whole-lesion histogram analysis. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Bladder cancer |2 nationallicence | |
| 690 | 7 | |a MRI |2 nationallicence | |
| 690 | 7 | |a Diffusion-weighted imaging |2 nationallicence | |
| 690 | 7 | |a Histogram |2 nationallicence | |
| 700 | 1 | |a Rosenkrantz |D Andrew |u Department of Radiology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | |
| 700 | 1 | |a Obele |D Chika |u Department of Radiology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | |
| 700 | 1 | |a Rusinek |D Henry |u Department of Radiology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | |
| 700 | 1 | |a Balar |D Arjun |u Division of Hematology & Oncology, Department of Medicine, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | |
| 700 | 1 | |a Huang |D William |u Division of Urologic Oncology, Department of Urology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | |
| 700 | 1 | |a Deng |D Fang-Ming |u Department of Pathology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | |
| 700 | 1 | |a Ream |D Justin |u Department of Radiology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/2(2015-02-01), 327-332 |x 0942-8925 |q 40:2<327 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0213-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0213-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rosenkrantz |D Andrew |u Department of Radiology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Obele |D Chika |u Department of Radiology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Rusinek |D Henry |u Department of Radiology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Balar |D Arjun |u Division of Hematology & Oncology, Department of Medicine, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Huang |D William |u Division of Urologic Oncology, Department of Urology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Deng |D Fang-Ming |u Department of Pathology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ream |D Justin |u Department of Radiology, NYU Langone Medical Center, 550 First Avenue, 10016, New York, NY, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/2(2015-02-01), 327-332 |x 0942-8925 |q 40:2<327 |1 2015 |2 40 |o 261 | ||