Evaluation of 68Ga-DOTANOC PET/CT imaging in a large exclusive population of pancreatic neuroendocrine tumors
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| 024 | 7 | 0 | |a 10.1007/s00261-014-0219-5 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00261-014-0219-5 | ||
| 245 | 0 | 0 | |a Evaluation of 68Ga-DOTANOC PET/CT imaging in a large exclusive population of pancreatic neuroendocrine tumors |h [Elektronische Daten] |c [Punit Sharma, Saurabh Arora, Varun Dhull, Niraj Naswa, Rakesh Kumar, Ariachery Ammini, Chandrasekhar Bal] |
| 520 | 3 | |a Purpose: To evaluate the diagnostic accuracy of 68Ga-DOTANOC PET/CT imaging in a large exclusive population of pancreatic neuroendocrine tumors (NETs). Methods: Data of 141 (mean age 46.2±15.2years) patients who underwent 178 68Ga-DOTANOC PET/CT studies for diagnosis/staging (n=88) and restaging (n=90) of pancreatic NET were retrospectively analyzed. PET/CT results were compared to conventional imaging (CIM) when available (n=86). Histopathology and/or clinical/imaging follow-up (minimum 6months) were used as reference standard. Results: The overall sensitivity, specificity, and accuracy of 68Ga-DOTANOC PET/CT were 85.7%, 79.1%, and 84.8%. The corresponding values were 73%, 50%, and 70.4% for diagnosis/staging groups and 98.6%, 100%, and 98.8% for restaging groups. The accuracy was significantly higher for restaging as compared to diagnosis/staging (P<0.0001) and in non-insulinoma tumors than insulinomas (P<0.0001). The SUVmax of primary tumors was significantly higher than metastatic lesions overall (P=0.001), as well as in diagnosis/staging (P=0.041) and restaging (P=0.0003) subgroups. When available, CIM was less specific than 68Ga-DOTANOC PET/CT (P<0.001) and showed fewer lesions. Conclusions: 68Ga-DOTANOC PET/CT is useful for diagnosis/staging and restaging of patients with pancreatic NET. It demonstrates more lesions compared to CIM and is more specific. | |
| 540 | |a Springer Science+Business Media New York, 2014 | ||
| 690 | 7 | |a Pancreas |2 nationallicence | |
| 690 | 7 | |a Neuroendocrine tumor |2 nationallicence | |
| 690 | 7 | |a 68Ga-DOTANOC PET/CT |2 nationallicence | |
| 690 | 7 | |a Staging |2 nationallicence | |
| 690 | 7 | |a Restaging |2 nationallicence | |
| 700 | 1 | |a Sharma |D Punit |u Department of Nuclear Medicine and PET/CT, Eastern Diagnostics India Ltd., Kolkata, India |4 aut | |
| 700 | 1 | |a Arora |D Saurabh |u Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India |4 aut | |
| 700 | 1 | |a Dhull |D Varun |u Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India |4 aut | |
| 700 | 1 | |a Naswa |D Niraj |u Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India |4 aut | |
| 700 | 1 | |a Kumar |D Rakesh |u Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India |4 aut | |
| 700 | 1 | |a Ammini |D Ariachery |u Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India |4 aut | |
| 700 | 1 | |a Bal |D Chandrasekhar |u Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India |4 aut | |
| 773 | 0 | |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/2(2015-02-01), 299-309 |x 0942-8925 |q 40:2<299 |1 2015 |2 40 |o 261 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00261-014-0219-5 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00261-014-0219-5 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sharma |D Punit |u Department of Nuclear Medicine and PET/CT, Eastern Diagnostics India Ltd., Kolkata, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Arora |D Saurabh |u Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dhull |D Varun |u Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Naswa |D Niraj |u Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kumar |D Rakesh |u Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ammini |D Ariachery |u Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bal |D Chandrasekhar |u Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Abdominal Imaging |d Springer US; http://www.springer-ny.com |g 40/2(2015-02-01), 299-309 |x 0942-8925 |q 40:2<299 |1 2015 |2 40 |o 261 | ||