caa a22 4500 605497303 CHVBK 20210128100540.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10441-014-9241-9 doi (NATIONALLICENCE)springer-10.1007/s10441-014-9241-9 An Embedded Automaton to Monitor the Glycolysis Process in Pancreatic β-Cells [Elektronische Daten] [R. Selvakumar, M. Muhammad, G. Devi] An embedded automaton is introduced to monitor the whole glycolysis process in pancreatic β-cell and it is a hybridization of both non-deterministic finite automaton and push-down automaton. The set of irreversible and reversible reactions in the glycolysis process are related to non-deterministic finite automaton and push-down automaton respectively. The embedded automaton is used to observe the glucose metabolism with the states of acceptance and rejection. The acceptance state of the embedded automaton depicts the normal level of glycolysis and insulin secretion. The rejection state of this machine shows inhibition of glycolysis which obstructs the secretion of insulin. The subsequent low level of insulin leads to the high blood glucose level also known as hyperglycemia. In this study, the designed machine can be used to regulate the process of glycolysis through a group of regulatory glycolytic enzymes for the treatment of Diabetes mellitus at molecular level. Springer Science+Business Media Dordrecht, 2014 Embedded automata nationallicence Enzymes nationallicence Glycolysis nationallicence Pancreatic β-cell nationallicence EA : Embedded automata nationallicence GK : Glucokinase nationallicence GKAs : Glucokinase activators nationallicence GLUT : Glucose transporter nationallicence NFA : Non-deterministic finite automata nationallicence PDA : Push-down automata nationallicence NAD : Nicotinamide adenine dinucleotide nationallicence Selvakumar R. School of Advanced Sciences, VIT University, 632014, Vellore, Tamil Nadu, India aut Muhammad M. School of Advanced Sciences, VIT University, 632014, Vellore, Tamil Nadu, India aut Devi G. Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany aut Acta Biotheoretica Springer Netherlands 63/1(2015-03-01), 23-31 0001-5342 63:1<23 2015 63 10441 https://doi.org/10.1007/s10441-014-9241-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10441-014-9241-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Selvakumar R. School of Advanced Sciences, VIT University, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 700 1- Muhammad M. School of Advanced Sciences, VIT University, 632014, Vellore, Tamil Nadu, India aut NATIONALLICENCE 700 1- Devi G. Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany aut NATIONALLICENCE 773 0- Acta Biotheoretica Springer Netherlands 63/1(2015-03-01), 23-31 0001-5342 63:1<23 2015 63 10441