caa a22 4500 60549732X CHVBK 20210128100540.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10441-015-9250-3 doi (NATIONALLICENCE)springer-10.1007/s10441-015-9250-3 Implementation of a Model of Bodily Fluids Regulation [Elektronische Daten] [Julie Fontecave-Jallon, S. Thomas] The classic model of blood pressure regulation by Guyton et al. (Annu Rev Physiol 34:13-46, 1972a; Ann Biomed Eng 1:254-281, 1972b) set a new standard for quantitative exploration of physiological function and led to important new insights, some of which still remain the focus of debate, such as whether the kidney plays the primary role in the genesis of hypertension (Montani et al. in Exp Physiol 24:41-54, 2009a; Exp Physiol 94:382-388, 2009b; Osborn et al. in Exp Physiol 94:389-396, 2009a; Exp Physiol 94:388-389, 2009b). Key to the success of this model was the fact that the authors made the computer code (in FORTRAN) freely available and eventually provided a convivial user interface for exploration of model behavior on early microcomputers (Montani et al. in Int J Bio-med Comput 24:41-54, 1989). Ikeda et al. (Ann Biomed Eng 7:135-166, 1979) developed an offshoot of the Guyton model targeting especially the regulation of body fluids and acid-base balance; their model provides extended renal and respiratory functions and would be a good basis for further extensions. In the interest of providing a simple, useable version of Ikeda et al.'s model and to facilitate further such extensions, we present a practical implementation of the model of Ikeda et al. (Ann Biomed Eng 7:135-166, 1979), using the ODE solver Berkeley Madonna. The Author(s), 2015 Computational physiology nationallicence Acid-base balance nationallicence Mathematical modelling nationallicence Virtual physiological human (VPH) nationallicence Fontecave-Jallon Julie CNRS, TIMC-IMAG Laboratory CNRS UMR 5525, PRETA Team, University Joseph Fourier-Grenoble 1, 38041, Grenoble, France aut Thomas S. IR4M UMR8081 CNRS, University Paris-Sud, Orsay, France aut Acta Biotheoretica Springer Netherlands 63/3(2015-09-01), 269-282 0001-5342 63:3<269 2015 63 10441 https://doi.org/10.1007/s10441-015-9250-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10441-015-9250-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fontecave-Jallon Julie CNRS, TIMC-IMAG Laboratory CNRS UMR 5525, PRETA Team, University Joseph Fourier-Grenoble 1, 38041, Grenoble, France aut NATIONALLICENCE 700 1- Thomas S. IR4M UMR8081 CNRS, University Paris-Sud, Orsay, France aut NATIONALLICENCE 773 0- Acta Biotheoretica Springer Netherlands 63/3(2015-09-01), 269-282 0001-5342 63:3<269 2015 63 10441