caa a22 4500 605497370 CHVBK 20210128100541.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s10441-015-9249-9 doi (NATIONALLICENCE)springer-10.1007/s10441-015-9249-9 A Conceptual Model of Morphogenesis and Regeneration [Elektronische Daten] [A. Tosenberger, N. Bessonov, M. Levin, N. Reinberg, V. Volpert, N. Morozova] This paper is devoted to computer modelling of the development and regeneration of multicellular biological structures. Some species (e.g. planaria and salamanders) are able to regenerate parts of their body after amputation damage, but the global rules governing cooperative cell behaviour during morphogenesis are not known. Here, we consider a simplified model organism, which consists of tissues formed around special cells that can be interpreted as stem cells. We assume that stem cells communicate with each other by a set of signals, and that the values of these signals depend on the distance between cells. Thus the signal distribution characterizes location of stem cells. If the signal distribution is changed, then the difference between the initial and the current signal distribution affects the behaviour of stem cells—e.g. as a result of an amputation of a part of tissue the signal distribution changes which stimulates stem cells to migrate to new locations, appropriate for regeneration of the proper pattern. Moreover, as stem cells divide and form tissues around them, they control the form and the size of regenerating tissues. This two-level organization of the model organism, with global regulation of stem cells and local regulation of tissues, allows its reproducible development and regeneration. Springer Science+Business Media Dordrecht, 2015 Regeneration nationallicence Morphogenesis nationallicence Cell memory nationallicence Target morphology nationallicence Tosenberger A. Institut des Hautes Études Scientifiques, 91440, Bures-sur-Yvette, France aut Bessonov N. Institute of Mechanical Engineering Problems, 199178, Saint Petersburg, Russia aut Levin M. Department of Biology, Tufts Center for Regenerative & Developmental Biology, Tufts University, 02155, Medford, MA, USA aut Reinberg N. Institute of Mechanical Engineering Problems, 199178, Saint Petersburg, Russia aut Volpert V. Institut Camille Jordan, UMR 5208 CNRS, University Lyon 1, 69622, Villeurbanne, France aut Morozova N. Institut des Hautes Études Scientifiques, 91440, Bures-sur-Yvette, France aut Acta Biotheoretica Springer Netherlands 63/3(2015-09-01), 283-294 0001-5342 63:3<283 2015 63 10441 https://doi.org/10.1007/s10441-015-9249-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10441-015-9249-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tosenberger A. Institut des Hautes Études Scientifiques, 91440, Bures-sur-Yvette, France aut NATIONALLICENCE 700 1- Bessonov N. Institute of Mechanical Engineering Problems, 199178, Saint Petersburg, Russia aut NATIONALLICENCE 700 1- Levin M. Department of Biology, Tufts Center for Regenerative & Developmental Biology, Tufts University, 02155, Medford, MA, USA aut NATIONALLICENCE 700 1- Reinberg N. Institute of Mechanical Engineering Problems, 199178, Saint Petersburg, Russia aut NATIONALLICENCE 700 1- Volpert V. Institut Camille Jordan, UMR 5208 CNRS, University Lyon 1, 69622, Villeurbanne, France aut NATIONALLICENCE 700 1- Morozova N. Institut des Hautes Études Scientifiques, 91440, Bures-sur-Yvette, France aut NATIONALLICENCE 773 0- Acta Biotheoretica Springer Netherlands 63/3(2015-09-01), 283-294 0001-5342 63:3<283 2015 63 10441