caa a22 4500 605497451 CHVBK 20210128100541.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10441-015-9264-x doi (NATIONALLICENCE)springer-10.1007/s10441-015-9264-x Travelling Waves of Cell Differentiation [Elektronische Daten] [M. Benmir, N. Bessonov, S. Boujena, V. Volpert] The paper is devoted to modelling of cell differentiation in an initially homogeneous cell population. The mechanism which provides coexistence of two cell lineages in the initially homogeneous cell population is suggested. If cell differentiation is initiated locally in space in the population of undifferentiated cells, it can propagate as a travelling wave converting undifferentiated cells into differentiated ones. We suggest a model of this process which takes into account intracellular regulation, extracellular regulation and different cell types. They include undifferentiated cells and two types of differentiated cells. When a cell differentiates, its choice between two types of differentiated cells is determined by the concentrations of intracellular proteins. Differentiated cells can either stimulate differentiation into their own cell lineage or into another cell lineage. In the case of the positive feedback, only one lineage of differentiated cells will finally appear. In the case of negative feedback, both of them can coexist. In this case a periodic spatial pattern emerges behind the wave. Springer Science+Business Media Dordrecht, 2015 Cell differentiation nationallicence Lineage choice nationallicence Reaction-diffusion waves nationallicence Pattern formation nationallicence Benmir M. Faculté des Sciences, University Hassan II of Casablanca, 20100, Casablanca, Maroc aut Bessonov N. Institute of Problems of Mechanical Engineering, Russian Academy of Sciences, 199178, Saint Petersburg, Russia aut Boujena S. Faculté des Sciences, University Hassan II of Casablanca, 20100, Casablanca, Maroc aut Volpert V. Institut Camille Jordan, UMR 5208 CNRS, University Lyon 1, 69622, Villeurbanne, France aut Acta Biotheoretica Springer Netherlands 63/4(2015-12-01), 381-395 0001-5342 63:4<381 2015 63 10441 https://doi.org/10.1007/s10441-015-9264-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10441-015-9264-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Benmir M. Faculté des Sciences, University Hassan II of Casablanca, 20100, Casablanca, Maroc aut NATIONALLICENCE 700 1- Bessonov N. Institute of Problems of Mechanical Engineering, Russian Academy of Sciences, 199178, Saint Petersburg, Russia aut NATIONALLICENCE 700 1- Boujena S. Faculté des Sciences, University Hassan II of Casablanca, 20100, Casablanca, Maroc aut NATIONALLICENCE 700 1- Volpert V. Institut Camille Jordan, UMR 5208 CNRS, University Lyon 1, 69622, Villeurbanne, France aut NATIONALLICENCE 773 0- Acta Biotheoretica Springer Netherlands 63/4(2015-12-01), 381-395 0001-5342 63:4<381 2015 63 10441