caa a22 4500 605497516 CHVBK 20210128100541.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10441-015-9248-x doi (NATIONALLICENCE)springer-10.1007/s10441-015-9248-x Menchón Silvia IFEG-CONICET and FaMAF, Universidad Nacional de Córdoba, Medina Allende s/n, Ciudad Universitaria, 5000, Córdoba, Argentina aut The Effect of Intrinsic and Acquired Resistances on Chemotherapy Effectiveness [Elektronische Daten] [Silvia Menchón] Although chemotherapy is one of the most common treatments for cancer, it can be only partially successful. Drug resistance is the main cause of the failure of chemotherapy. In this work, we present a mathematical model to study the impact of both intrinsic (preexisting) and acquired (induced by the drugs) resistances on chemotherapy effectiveness. Our simulations show that intrinsic resistance could be as dangerous as acquired resistance. In particular, our simulations suggest that tumors composed by even a small fraction of intrinsically resistant cells may lead to an unsuccessful therapy very quickly. Our results emphasize the importance of monitoring both intrinsic and acquired resistances during treatment in order to succeed and the importance of doing more experimental and genetic research in order to develop a pretreatment clinical test to avoid intrinsic resistance. Springer Science+Business Media Dordrecht, 2015 Mathematical modeling and simulations nationallicence Chemotherapy nationallicence Intrinsic resistance nationallicence Acquired resistance nationallicence Acta Biotheoretica Springer Netherlands 63/2(2015-06-01), 113-127 0001-5342 63:2<113 2015 63 10441 https://doi.org/10.1007/s10441-015-9248-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10441-015-9248-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Menchón Silvia IFEG-CONICET and FaMAF, Universidad Nacional de Córdoba, Medina Allende s/n, Ciudad Universitaria, 5000, Córdoba, Argentina aut NATIONALLICENCE 773 0- Acta Biotheoretica Springer Netherlands 63/2(2015-06-01), 113-127 0001-5342 63:2<113 2015 63 10441