Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA

Verfasser / Beitragende:
[Noemi Ruiz-Lopez, Sarah Usher, Olga Sayanova, Johnathan Napier, Richard Haslam]
Ort, Verlag, Jahr:
2015
Enthalten in:
Applied Microbiology and Biotechnology, 99/1(2015-01-01), 143-154
Format:
Artikel (online)
ID: 605498148
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024 7 0 |a 10.1007/s00253-014-6217-2  |2 doi 
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245 0 0 |a Modifying the lipid content and composition of plant seeds: engineering the production of LC-PUFA  |h [Elektronische Daten]  |c [Noemi Ruiz-Lopez, Sarah Usher, Olga Sayanova, Johnathan Napier, Richard Haslam] 
520 3 |a Omega-3 fatty acids are characterized by a double bond at the third carbon atom from the end of the carbon chain. Latterly, long chain polyunsaturated omega-3 fatty acids such as eicosapentaenoic acid (EPA; 20:5Δ5,8,11,14,17) and docosahexanoic acid (DHA; 22:6 Δ4,7,10,13,16,19), which typically only enter the human diet via the consumption of oily fish, have attracted much attention. The health benefits of the omega-3 LC-PUFAs EPA and DHA are now well established. Given the desire for a sustainable supply of omega-LC-PUFA, efforts have focused on enhancing the composition of vegetable oils to include these important fatty acids. Specifically, EPA and DHA have been the focus of much study, with the ultimate goal of producing a terrestrial plant-based source of these so-called fish oils. Over the last decade, many genes encoding the primary LC-PUFA biosynthetic activities have been identified and characterized. This has allowed the reconstitution of the LC-PUFA biosynthetic pathway in oilseed crops, producing transgenic plants engineered to accumulate omega-3 LC-PUFA to levels similar to that found in fish oil. In this review, we will describe the most recent developments in this field and the challenges of overwriting endogenous seed lipid metabolism to maximize the accumulation of these important fatty acids. 
540 |a The Author(s), 2014 
690 7 |a Omega-3 fatty acids  |2 nationallicence 
690 7 |a Polyunsaturated fatty acid  |2 nationallicence 
690 7 |a Triacylglycerol  |2 nationallicence 
690 7 |a Transgenic plant  |2 nationallicence 
690 7 |a Oilseed  |2 nationallicence 
690 7 |a Camelina sativa  |2 nationallicence 
700 1 |a Ruiz-Lopez  |D Noemi  |u Department of Biological Chemistry, Rothamsted Research, AL5 2JQ, Harpenden, Herts, UK  |4 aut 
700 1 |a Usher  |D Sarah  |u Department of Biological Chemistry, Rothamsted Research, AL5 2JQ, Harpenden, Herts, UK  |4 aut 
700 1 |a Sayanova  |D Olga  |u Department of Biological Chemistry, Rothamsted Research, AL5 2JQ, Harpenden, Herts, UK  |4 aut 
700 1 |a Napier  |D Johnathan  |u Department of Biological Chemistry, Rothamsted Research, AL5 2JQ, Harpenden, Herts, UK  |4 aut 
700 1 |a Haslam  |D Richard  |u Department of Biological Chemistry, Rothamsted Research, AL5 2JQ, Harpenden, Herts, UK  |4 aut 
773 0 |t Applied Microbiology and Biotechnology  |d Springer Berlin Heidelberg  |g 99/1(2015-01-01), 143-154  |x 0175-7598  |q 99:1<143  |1 2015  |2 99  |o 253 
856 4 0 |u https://doi.org/10.1007/s00253-014-6217-2  |q text/html  |z Onlinezugriff via DOI 
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900 7 |a Metadata rights reserved  |b Springer special CC-BY-NC licence  |2 nationallicence 
908 |D 1  |a review-article  |2 jats 
949 |B NATIONALLICENCE  |F NATIONALLICENCE  |b NL-springer 
950 |B NATIONALLICENCE  |P 856  |E 40  |u https://doi.org/10.1007/s00253-014-6217-2  |q text/html  |z Onlinezugriff via DOI 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Ruiz-Lopez  |D Noemi  |u Department of Biological Chemistry, Rothamsted Research, AL5 2JQ, Harpenden, Herts, UK  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Usher  |D Sarah  |u Department of Biological Chemistry, Rothamsted Research, AL5 2JQ, Harpenden, Herts, UK  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Sayanova  |D Olga  |u Department of Biological Chemistry, Rothamsted Research, AL5 2JQ, Harpenden, Herts, UK  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Napier  |D Johnathan  |u Department of Biological Chemistry, Rothamsted Research, AL5 2JQ, Harpenden, Herts, UK  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Haslam  |D Richard  |u Department of Biological Chemistry, Rothamsted Research, AL5 2JQ, Harpenden, Herts, UK  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Applied Microbiology and Biotechnology  |d Springer Berlin Heidelberg  |g 99/1(2015-01-01), 143-154  |x 0175-7598  |q 99:1<143  |1 2015  |2 99  |o 253