caa a22 4500 605498156 CHVBK 20210128100544.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00253-014-6192-7 doi (NATIONALLICENCE)springer-10.1007/s00253-014-6192-7 Heimel Kai Institut für Mikrobiologie & Genetik, Georg-August-Universität, Grisebachstr. 8, 37077, Göttingen, Germany aut Unfolded protein response in filamentous fungi—implications in biotechnology [Elektronische Daten] [Kai Heimel] The unfolded protein response (UPR) represents a mechanism to preserve endoplasmic reticulum (ER) homeostasis that is conserved in eukaryotes. ER stress caused by the accumulation of potentially toxic un- or misfolded proteins in the ER triggers UPR activation and the induction of genes important for protein folding in the ER, ER expansion, and transport from and to the ER. Along with this adaptation, the overall capacity for protein secretion is markedly increased by the UPR. In filamentous fungi, various approaches to employ the UPR for improved production of homologous and heterologous proteins have been investigated. As the effects on protein production were strongly dependent on the expressed protein, generally applicable strategies have to be developed. A combination of transcriptomic approaches monitoring secretion stress and basic research on the UPR mechanism provided novel and important insight into the complex regulatory cross-connections between UPR signalling, cellular physiology, and developmental processes. It will be discussed how this increasing knowledge on the UPR might stimulate the development of novel strategies for using the UPR as a tool in biotechnology. Springer-Verlag Berlin Heidelberg, 2014 Unfolded protein response nationallicence Protein secretion nationallicence Fungal development nationallicence Filamentous fungi nationallicence Aspergillus niger nationallicence Biotechnology nationallicence Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/1(2015-01-01), 121-132 0175-7598 99:1<121 2015 99 253 https://doi.org/10.1007/s00253-014-6192-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-014-6192-7 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Heimel Kai Institut für Mikrobiologie & Genetik, Georg-August-Universität, Grisebachstr. 8, 37077, Göttingen, Germany aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/1(2015-01-01), 121-132 0175-7598 99:1<121 2015 99 253