Evidence for cholesterol-lowering activity by Bifidobacterium bifidum PRL2010 through gut microbiota modulation
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| 008 | 210128e20150801xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00253-015-6564-7 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6564-7 | ||
| 245 | 0 | 0 | |a Evidence for cholesterol-lowering activity by Bifidobacterium bifidum PRL2010 through gut microbiota modulation |h [Elektronische Daten] |c [Ilaria Zanotti, Francesca Turroni, Antonio Piemontese, Leonardo Mancabelli, Christian Milani, Alice Viappiani, Gilda Prevedini, Borja Sanchez, Abelardo Margolles, Lisa Elviri, Bernini Franco, Douwe van Sinderen, Marco Ventura] |
| 520 | 3 | |a Bifidobacteria are members of the human gut microbiota, which are known to influence the metabolic abilities of their host. Here, we investigated the capabilities of bifidobacteria to reduce cholesterol levels in synthetic growth media, clearly demonstrating assimilation of this molecule by particular bifidobacterial strains, including Bifidobacterium bifidum PRL2010 (LMG S-28692). The transcriptomic analysis of PRL2010 cells cultivated in the presence of cholesterol revealed a significantly increased transcription level of genes encoding putative transporters and reductases, indicative of specific mechanisms for cholesterol assimilation as well as cholesterol conversion to coprostanol. Cholesterol lowering activity of B. bifidum PRL2010 cells was further evaluated by means of an in vivo murine model, showing that the fecal microbiota of mice is modified toward those bacteria involved in the metabolism of cholesterol. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Bifidobacterium |2 nationallicence | |
| 690 | 7 | |a Cholesterol |2 nationallicence | |
| 690 | 7 | |a Gut microbiota |2 nationallicence | |
| 690 | 7 | |a Functional genomics |2 nationallicence | |
| 700 | 1 | |a Zanotti |D Ilaria |u Department of Pharmacy, University of Parma, Parma, Italy |4 aut | |
| 700 | 1 | |a Turroni |D Francesca |u Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Western Road, Cork, Ireland |4 aut | |
| 700 | 1 | |a Piemontese |D Antonio |u Department of Pharmacy, University of Parma, Parma, Italy |4 aut | |
| 700 | 1 | |a Mancabelli |D Leonardo |u Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy |4 aut | |
| 700 | 1 | |a Milani |D Christian |u Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy |4 aut | |
| 700 | 1 | |a Viappiani |D Alice |u GenProbio srl, Parma, Italy |4 aut | |
| 700 | 1 | |a Prevedini |D Gilda |u Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy |4 aut | |
| 700 | 1 | |a Sanchez |D Borja |u Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Villaviciosa, Asturias, Spain |4 aut | |
| 700 | 1 | |a Margolles |D Abelardo |u Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Villaviciosa, Asturias, Spain |4 aut | |
| 700 | 1 | |a Elviri |D Lisa |u Department of Pharmacy, University of Parma, Parma, Italy |4 aut | |
| 700 | 1 | |a Franco |D Bernini |u Department of Pharmacy, University of Parma, Parma, Italy |4 aut | |
| 700 | 1 | |a van Sinderen |D Douwe |u Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Western Road, Cork, Ireland |4 aut | |
| 700 | 1 | |a Ventura |D Marco |u Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/16(2015-08-01), 6813-6829 |x 0175-7598 |q 99:16<6813 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6564-7 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6564-7 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zanotti |D Ilaria |u Department of Pharmacy, University of Parma, Parma, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Turroni |D Francesca |u Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Western Road, Cork, Ireland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Piemontese |D Antonio |u Department of Pharmacy, University of Parma, Parma, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mancabelli |D Leonardo |u Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Milani |D Christian |u Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Viappiani |D Alice |u GenProbio srl, Parma, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Prevedini |D Gilda |u Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sanchez |D Borja |u Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Villaviciosa, Asturias, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Margolles |D Abelardo |u Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Villaviciosa, Asturias, Spain |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Elviri |D Lisa |u Department of Pharmacy, University of Parma, Parma, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Franco |D Bernini |u Department of Pharmacy, University of Parma, Parma, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a van Sinderen |D Douwe |u Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Western Road, Cork, Ireland |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ventura |D Marco |u Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/16(2015-08-01), 6813-6829 |x 0175-7598 |q 99:16<6813 |1 2015 |2 99 |o 253 | ||