caa a22 4500 605498504 CHVBK 20210128100546.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00253-015-6849-x doi (NATIONALLICENCE)springer-10.1007/s00253-015-6849-x β-(1→3),(1→6)-Glucans: medicinal activities, characterization, biosynthesis and new horizons [Elektronische Daten] [Nicole Dalonso, Gustavo Goldman, Regina Gern] Biological activities of medicinal mushrooms have been attributed to β-(1→3),(1→6)-glucans that are present in the cell wall of fungi and some plants. Antitumor, immunomodulatory, antimicrobial, antinociception, antiinflammatory, prebiotic, antioxidant, and antidiabetic are some of different properties already described for β-(1→3),(1→6)-glucans. Immune activation systems, including specific β-glucan receptors like Dectin-1, complement (CR3), and Toll (TLR), have been identified to clarify these biological effects. The β-(1→3)-glucans are synthesized by β-(1→3)-glucan synthase (GLS), an enzyme belonging to the glucosyltransferase group, which has a catalytic unit (FKS) and another regulatory (RHO). The mechanisms for adding β-(1→6) branches to the non-reducing ends of the β-(1→3)-glucan chains are unclear until now. Due to the biological importance of β-(1→3),(1→6)-glucan, it is necessary to understand the biochemical and molecular mechanisms of its synthesis, both to optimize the production of bioactive compounds and to develop antifungal drugs that interrupt this process. Therefore, the aim of this review is to gather information about the potential of β-(1→3),(1→6)-glucans, their methods of isolation, purification, and chemical characterization, as well as howthese biomolecules are synthesized by fungi and what studies involving biotechnology or molecular biology have contributed to this subject. Springer-Verlag Berlin Heidelberg, 2015 β-(1→3),(1→6)-Glucans nationallicence β-(1→3)-Glucan synthase nationallicence Medicinal activities nationallicence Characterization nationallicence Biotechnology nationallicence Molecular biology nationallicence Dalonso Nicole Programa de Pós Graduação em Saúde e Meio Ambiente, Universidade da Região de Joinville, UNIVILLE, P.O. Box 246, 89201-972, Joinville, SC, Brazil aut Goldman Gustavo Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo—INCT do Bioetanol, Av. do Café S/N, 14040-903, Ribeirão Preto, SP, Brazil aut Gern Regina Programa de Pós Graduação em Saúde e Meio Ambiente, Universidade da Região de Joinville, UNIVILLE, P.O. Box 246, 89201-972, Joinville, SC, Brazil aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/19(2015-10-01), 7893-7906 0175-7598 99:19<7893 2015 99 253 https://doi.org/10.1007/s00253-015-6849-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6849-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dalonso Nicole Programa de Pós Graduação em Saúde e Meio Ambiente, Universidade da Região de Joinville, UNIVILLE, P.O. Box 246, 89201-972, Joinville, SC, Brazil aut NATIONALLICENCE 700 1- Goldman Gustavo Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo—INCT do Bioetanol, Av. do Café S/N, 14040-903, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Gern Regina Programa de Pós Graduação em Saúde e Meio Ambiente, Universidade da Região de Joinville, UNIVILLE, P.O. Box 246, 89201-972, Joinville, SC, Brazil aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/19(2015-10-01), 7893-7906 0175-7598 99:19<7893 2015 99 253