caa a22 4500 605498598 CHVBK 20210128100547.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00253-015-6844-2 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6844-2 Antibacterial properties of l -amino acid oxidase: mechanisms of action and perspectives for therapeutic applications [Elektronische Daten] [Kosuke Kasai, Takashi Ishikawa, Toshiya Nakamura, Tomisato Miura] Venom, the mucus layer covering the body surface, ink glands, mammary glands, milk, and various animal secretory functions as both a physical and chemical defense barrier against bacteria and virus infections. Previously, several studies reported that l-amino acid oxidases (LAAOs) present in animal secretary fluids have strong antimicrobial activities and selective cytotoxic activities against Gram-positive and Gram-negative bacteria, various pathogenic bacteria, viruses, and parasite species. These LAAOs catalyze oxidative deamination of an l-amino acid substrate with the generation of hydrogen peroxide. The antibacterial activity of LAAOs is completely inhibited by catalase; thus, LAAOs kill bacteria by the hydrogen peroxide generated from the oxidation of l-amino acid substrates. This review focuses on the selective, specific, and local antibacterial actions of various LAAOs that may be used as novel therapeutic agents against infectious diseases. LAAOs that are suitable leads for combating multidrug-resistant bacterial infections are also studied. Springer-Verlag Berlin Heidelberg, 2015 Antibacterial protein nationallicence l -amino acid oxidase nationallicence Multidrug-resistant bacteria nationallicence Hydrogen peroxide nationallicence Kasai Kosuke Department of Pathologic Analysis, Division of Medical Life Sciences, Graduate School of Health Sciences, Hirosaki University, Aomori, Japan aut Ishikawa Takashi Department of Biomedical Sciences, Division of Medical Life Sciences, Graduate School of Health Sciences, Hirosaki University, Aomori, Japan aut Nakamura Toshiya Department of Biomedical Sciences, Division of Medical Life Sciences, Graduate School of Health Sciences, Hirosaki University, Aomori, Japan aut Miura Tomisato Department of Pathologic Analysis, Division of Medical Life Sciences, Graduate School of Health Sciences, Hirosaki University, Aomori, Japan aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/19(2015-10-01), 7847-7857 0175-7598 99:19<7847 2015 99 253 https://doi.org/10.1007/s00253-015-6844-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6844-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kasai Kosuke Department of Pathologic Analysis, Division of Medical Life Sciences, Graduate School of Health Sciences, Hirosaki University, Aomori, Japan aut NATIONALLICENCE 700 1- Ishikawa Takashi Department of Biomedical Sciences, Division of Medical Life Sciences, Graduate School of Health Sciences, Hirosaki University, Aomori, Japan aut NATIONALLICENCE 700 1- Nakamura Toshiya Department of Biomedical Sciences, Division of Medical Life Sciences, Graduate School of Health Sciences, Hirosaki University, Aomori, Japan aut NATIONALLICENCE 700 1- Miura Tomisato Department of Pathologic Analysis, Division of Medical Life Sciences, Graduate School of Health Sciences, Hirosaki University, Aomori, Japan aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/19(2015-10-01), 7847-7857 0175-7598 99:19<7847 2015 99 253