caa a22 4500 605499446 CHVBK 20210128100551.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00253-015-6920-7 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6920-7 Mechanisms of fatty acid synthesis in marine fungus-like protists [Elektronische Daten] [Yunxuan Xie, Guangyi Wang] Thraustochytrids are unicellular fungus-like protists and are well known for their ability to produce interesting nutraceutical compounds. Significant efforts have been made to improve their efficient production of important fatty acids (FAs), mostly by optimizing fermentation conditions and selecting highly productive thraustochytrid strains. Furthermore, noticeable improvements have been made in understanding the mechanism of FA biosynthesis, allowing for a better understanding of how thraustochytrids assemble these unique metabolites and how their biosynthesis is coupled with other related pathways. This review summarizes recent achievements on two major FA biosynthesis pathways, the standard pathway and the polyketide synthase pathway, and detail features of individual enzymes involved in FA biosynthesis, biotechnological advances in pathway engineering and enzyme characterization, and the discovery of other pathways that affect the efficiency of FA accumulation. Perspectives of biotechnological potential application of thraustochytrids are also discussed. Springer-Verlag Berlin Heidelberg, 2015 Thraustochytrids nationallicence Fatty acid biosynthesis pathway nationallicence Polyunsaturated fatty acids nationallicence Docosahexaenoic acid nationallicence Xie Yunxuan Tianjin University Center for Marine Environmental Ecology, School of Environmental Science & Engineering, Tianjin University, 300072, Tianjin, China aut Wang Guangyi Tianjin University Center for Marine Environmental Ecology, School of Environmental Science & Engineering, Tianjin University, 300072, Tianjin, China aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/20(2015-10-01), 8363-8375 0175-7598 99:20<8363 2015 99 253 https://doi.org/10.1007/s00253-015-6920-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6920-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xie Yunxuan Tianjin University Center for Marine Environmental Ecology, School of Environmental Science & Engineering, Tianjin University, 300072, Tianjin, China aut NATIONALLICENCE 700 1- Wang Guangyi Tianjin University Center for Marine Environmental Ecology, School of Environmental Science & Engineering, Tianjin University, 300072, Tianjin, China aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/20(2015-10-01), 8363-8375 0175-7598 99:20<8363 2015 99 253