caa a22 4500 605499810 CHVBK 20210128100552.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00253-015-6404-9 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6404-9 Impacts of coexisting antibiotics, antibacterial residues, and heavy metals on the occurrence of erythromycin resistance genes in urban wastewater [Elektronische Daten] [Pin Gao, Shi He, Shenglin Huang, Kanzhu Li, Zhenhong Liu, Gang Xue, Weimin Sun] Antibiotic resistance is a global challenge and represents a growing threat on human health worldwide. Wastewater treatment plants (WWTPs) are generally considered as hotspots for control and/or dissemination of antibiotic resistance. The role of antibiotics, antibacterial residues, and heavy metals played on the evolution and spread of antibiotic resistance is still not well understood. Here, the occurrence of antibiotics (i.e., macrolides, tetracyclines, sulfonamides, and quinolones), antibacterial residues (i.e., triclosan), as well as heavy metals (i.e., cadmium, chromium, copper, zinc, lead, and nickel) in urban wastewater was investigated. Also, the abundances of erythromycin resistance genes (ERY-ARGs) including ere(A), ere(B), mef(A)/mef(E), erm(A), erm(B), erm(C), and msr(A)/msr(B) genes were screened. A relationship between certain antibiotics, antibacterial residues, and heavy metals and ERY-ARGs was demonstrated. ERY presented significant correlations (0.883 < r < 0.929, P < 0.05) with ere(A), ere(B), and mef(A)/mef(E) genes, while tetracycline exhibited a significant correlation (r = 0.829, P < 0.05) with erm(B) genes. It is noteworthy that triclosan correlated significantly (0.859 < r < 0.956, P < 0.05) with ere(A), ere(B), mef(A)/mef(E), and erm(B) genes. In addition, significantly positive correlations (0.823 < r < 0.871, P < 0.05) were observed between zinc and lead and certain ERY-ARGs (i.e., ere(B), mef(A)/mef(E), erm(B), etc.). Further investigations should be involved to elucidate the co-selection and/or cross-selection mechanisms due to co-existence of these selective factors in urban wastewater. Springer-Verlag Berlin Heidelberg, 2015 Antibiotic nationallicence Antibacterial residue nationallicence Heavy metal nationallicence Erythromycin resistance gene nationallicence Urban wastewater nationallicence Gao Pin College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut He Shi College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut Huang Shenglin College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut Li Kanzhu College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut Liu Zhenhong College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut Xue Gang College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut Sun Weimin Department of Environmental Sciences, Rutgers University, 08901, New Brunswick, NJ, USA aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/9(2015-05-01), 3971-3980 0175-7598 99:9<3971 2015 99 253 https://doi.org/10.1007/s00253-015-6404-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6404-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gao Pin College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut NATIONALLICENCE 700 1- He Shi College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut NATIONALLICENCE 700 1- Huang Shenglin College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut NATIONALLICENCE 700 1- Li Kanzhu College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut NATIONALLICENCE 700 1- Liu Zhenhong College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut NATIONALLICENCE 700 1- Xue Gang College of Environmental Science and Engineering, Donghua University, 201620, Shanghai, China aut NATIONALLICENCE 700 1- Sun Weimin Department of Environmental Sciences, Rutgers University, 08901, New Brunswick, NJ, USA aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/9(2015-05-01), 3971-3980 0175-7598 99:9<3971 2015 99 253