Biosynthesis and production of glycosylated flavonoids in Escherichia coli
current state and perspectives
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| 024 | 7 | 0 | |a 10.1007/s00253-015-6504-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6504-6 | ||
| 245 | 0 | 0 | |a Biosynthesis and production of glycosylated flavonoids in Escherichia coli |h [Elektronische Daten] |b current state and perspectives |c [Bong Kim, So Yang, So Kim, Mi Cha, Joong-Hoon Ahn] |
| 520 | 3 | |a Flavonoids are plant secondary metabolites containing several hydroxyl groups that are targets for modification reactions such as methylation and glycosylation. In plants, flavonoids are present as glycones. Although glucose is the most common sugar attached to flavonoids, arabinose, galactose, glucuronic acid, rhamnose, and xylose are also linked to flavonoids. Depending on the kind and the position of the attached sugar, flavonoid glycones show different biological properties. Flavonoid-O-glycosides are synthesized by uridine diphosphate-dependent glycosyltransferases (UGTs), which use nucleotide sugar as a sugar donor and a diverse compound as a sugar acceptor. Recently, diverse flavonoid-O-glycosides have been synthesized in Escherichia coli by introducing UGTs from plants and bacteria and modifying endogenous pathways. The nucleotide sugar biosynthesis pathway in E. coli has been engineered to provide the proper nucleotide sugar for flavonoid-O-glycoside biosynthesis. In this review, we will discuss recent advances in flavonoid-O-glycoside biosynthesis using engineered E. coli. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Flavonoid- O -glycoside |2 nationallicence | |
| 690 | 7 | |a Metabolic engineering |2 nationallicence | |
| 690 | 7 | |a UGT |2 nationallicence | |
| 700 | 1 | |a Kim |D Bong |u Department of Forest Resources, Gyeongnam National University of Science and Technology, 33 Dongjin-ro, 660-758, Jinju-si, Gyeongsangman-do, Republic of Korea |4 aut | |
| 700 | 1 | |a Yang |D So |u Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea |4 aut | |
| 700 | 1 | |a Kim |D So |u Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea |4 aut | |
| 700 | 1 | |a Cha |D Mi |u Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea |4 aut | |
| 700 | 1 | |a Ahn |D Joong-Hoon |u Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/7(2015-04-01), 2979-2988 |x 0175-7598 |q 99:7<2979 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6504-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6504-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Bong |u Department of Forest Resources, Gyeongnam National University of Science and Technology, 33 Dongjin-ro, 660-758, Jinju-si, Gyeongsangman-do, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yang |D So |u Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D So |u Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cha |D Mi |u Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ahn |D Joong-Hoon |u Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/7(2015-04-01), 2979-2988 |x 0175-7598 |q 99:7<2979 |1 2015 |2 99 |o 253 | ||