caa a22 4500 605500118 CHVBK 20210128100554.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00253-015-6504-6 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6504-6 Biosynthesis and production of glycosylated flavonoids in Escherichia coli [Elektronische Daten] current state and perspectives [Bong Kim, So Yang, So Kim, Mi Cha, Joong-Hoon Ahn] Flavonoids are plant secondary metabolites containing several hydroxyl groups that are targets for modification reactions such as methylation and glycosylation. In plants, flavonoids are present as glycones. Although glucose is the most common sugar attached to flavonoids, arabinose, galactose, glucuronic acid, rhamnose, and xylose are also linked to flavonoids. Depending on the kind and the position of the attached sugar, flavonoid glycones show different biological properties. Flavonoid-O-glycosides are synthesized by uridine diphosphate-dependent glycosyltransferases (UGTs), which use nucleotide sugar as a sugar donor and a diverse compound as a sugar acceptor. Recently, diverse flavonoid-O-glycosides have been synthesized in Escherichia coli by introducing UGTs from plants and bacteria and modifying endogenous pathways. The nucleotide sugar biosynthesis pathway in E. coli has been engineered to provide the proper nucleotide sugar for flavonoid-O-glycoside biosynthesis. In this review, we will discuss recent advances in flavonoid-O-glycoside biosynthesis using engineered E. coli. Springer-Verlag Berlin Heidelberg, 2015 Flavonoid- O -glycoside nationallicence Metabolic engineering nationallicence UGT nationallicence Kim Bong Department of Forest Resources, Gyeongnam National University of Science and Technology, 33 Dongjin-ro, 660-758, Jinju-si, Gyeongsangman-do, Republic of Korea aut Yang So Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea aut Kim So Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea aut Cha Mi Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea aut Ahn Joong-Hoon Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/7(2015-04-01), 2979-2988 0175-7598 99:7<2979 2015 99 253 https://doi.org/10.1007/s00253-015-6504-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6504-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Bong Department of Forest Resources, Gyeongnam National University of Science and Technology, 33 Dongjin-ro, 660-758, Jinju-si, Gyeongsangman-do, Republic of Korea aut NATIONALLICENCE 700 1- Yang So Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Kim So Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Cha Mi Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea aut NATIONALLICENCE 700 1- Ahn Joong-Hoon Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, 143-701, Seoul, Republic of Korea aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/7(2015-04-01), 2979-2988 0175-7598 99:7<2979 2015 99 253