caa a22 4500 605500479 CHVBK 20210128100556.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s00253-015-6643-9 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6643-9 Receptor for the F4 fimbriae of enterotoxigenic Escherichia coli (ETEC) [Elektronische Daten] [Pengpeng Xia, Yajie Zou, Yiting Wang, Yujie Song, Wei Liu, David Francis, Guoqiang Zhu] Infection with F4+ enterotoxigenic Escherichia coli (ETEC) responsible for diarrhea in neonatal and post-weaned piglets leads to great economic losses in the swine industry. These pathogenic bacteria express either of three fimbrial variants F4ab, F4ac, and F4ad, which have long been known for their importance in host infection and initiating protective immune responses. The initial step in infection for the bacterium is to adhere to host enterocytes through fimbriae-mediated recognition of receptors on the host cell surface. A number of receptors for ETEC F4 have now been described and characterized, but their functions are still poorly understood. The current review summarizes the latest research addressing the characteristics of F4 fimbriae receptors and the interactions of F4 fimbriae and their receptors on host cells. These include observations that as follows: (1) FaeG mediates the binding activities of F4 and is an essential component of the F4 fimbriae, (2) the F4 fimbrial receptor gene is located in a region of chromosome 13, (3) the biochemical properties of F4 fimbrial receptors that form the binding site of the bacterium are now recognized, and (4) specific receptors confer susceptibility/resistance to ETEC F4 infection in pigs. Characterizing the host-pathogen interaction will be crucial to understand the pathogenicity of the bacteria, provide insights into receptor activation of the innate immune system, and develop therapeutic strategies to prevent this illness. Springer-Verlag Berlin Heidelberg, 2015 Fimbriae-mediated receptor nationallicence Enterotoxigenic Escherichia coli (ETEC) F4+ nationallicence Infection and immunity nationallicence Xia Pengpeng College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut Zou Yajie College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut Wang Yiting College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut Song Yujie College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut Liu Wei College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut Francis David Department of Veterinary and Biomedical Sciences, South Dakota State University, 57007, Brookings, SD, USA aut Zhu Guoqiang College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/12(2015-06-01), 4953-4959 0175-7598 99:12<4953 2015 99 253 https://doi.org/10.1007/s00253-015-6643-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6643-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xia Pengpeng College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut NATIONALLICENCE 700 1- Zou Yajie College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut NATIONALLICENCE 700 1- Wang Yiting College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut NATIONALLICENCE 700 1- Song Yujie College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut NATIONALLICENCE 700 1- Liu Wei College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut NATIONALLICENCE 700 1- Francis David Department of Veterinary and Biomedical Sciences, South Dakota State University, 57007, Brookings, SD, USA aut NATIONALLICENCE 700 1- Zhu Guoqiang College of Veterinary Medicine, Yangzhou University, 12 East Wenhui Road, 225009, Yangzhou, China aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/12(2015-06-01), 4953-4959 0175-7598 99:12<4953 2015 99 253