Advances and needs for endotoxin-free production strains
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| 024 | 7 | 0 | |a 10.1007/s00253-015-6947-9 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6947-9 | ||
| 245 | 0 | 0 | |a Advances and needs for endotoxin-free production strains |h [Elektronische Daten] |c [Seiichi Taguchi, Toshihiko Ooi, Kouhei Mizuno, Hiromi Matsusaki] |
| 520 | 3 | |a The choice of an appropriate microbial host cell and suitable production conditions is crucial for the downstream processing of pharmaceutical- and food-grade products. Although Escherichia coli serves as a highly valuable leading platform for the production of value-added products, like most Gram-negative bacteria, this bacterium contains a potent immunostimulatory lipopolysaccharide (LPS), referred to as an endotoxin. In contrast, Gram-positive bacteria, notably Bacillus, lactic acid bacteria (LAB), Corynebacterium, and yeasts have been extensively used as generally recognized as safe (GRAS) endotoxin-free platforms for the production of a variety of products. This review summarizes the currently available knowledge on the utilization of these representative Gram-positive bacteria for the production of eco- and bio-friendly products, particularly natural polyesters, polyhydroxyalkanoates, bacteriocins, and membrane proteins. The successful case studies presented here serve to inspire the use of these microorganisms as a main-player or by-player depending on their individual properties for the industrial production of these desirable targets. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Food-grade Gram-positive bacteria |2 nationallicence | |
| 690 | 7 | |a Lipopolysaccharide |2 nationallicence | |
| 690 | 7 | |a Polyhydroxyalkanoates |2 nationallicence | |
| 690 | 7 | |a Bacteriocins |2 nationallicence | |
| 690 | 7 | |a Membrane proteins |2 nationallicence | |
| 690 | 7 | |a Yeasts |2 nationallicence | |
| 700 | 1 | |a Taguchi |D Seiichi |u Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, N13-W8, Kita-ku, 060-8628, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Ooi |D Toshihiko |u Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, N13-W8, Kita-ku, 060-8628, Sapporo, Japan |4 aut | |
| 700 | 1 | |a Mizuno |D Kouhei |u Department of Materials Science and Chemical Engineering, Kitakyushu National College of Technology, 5-20-1 Shii, Kokuraminami-ku, 802-0985, Kitakyushu, Japan |4 aut | |
| 700 | 1 | |a Matsusaki |D Hiromi |u Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, 3-1-100 Tsukide, Higashi-ku, 862-8502, Kumamoto, Japan |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/22(2015-11-01), 9349-9360 |x 0175-7598 |q 99:22<9349 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6947-9 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6947-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Taguchi |D Seiichi |u Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, N13-W8, Kita-ku, 060-8628, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ooi |D Toshihiko |u Division of Applied Chemistry, Graduate School of Engineering, Hokkaido University, N13-W8, Kita-ku, 060-8628, Sapporo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mizuno |D Kouhei |u Department of Materials Science and Chemical Engineering, Kitakyushu National College of Technology, 5-20-1 Shii, Kokuraminami-ku, 802-0985, Kitakyushu, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Matsusaki |D Hiromi |u Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, 3-1-100 Tsukide, Higashi-ku, 862-8502, Kumamoto, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/22(2015-11-01), 9349-9360 |x 0175-7598 |q 99:22<9349 |1 2015 |2 99 |o 253 | ||