Comparison of inhibitory activity of bioactive molecules on the dextransucrase from Streptococcus mutans
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| 024 | 7 | 0 | |a 10.1007/s00253-015-6693-z |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6693-z | ||
| 245 | 0 | 0 | |a Comparison of inhibitory activity of bioactive molecules on the dextransucrase from Streptococcus mutans |h [Elektronische Daten] |c [Choon Lee, Jae Park] |
| 520 | 3 | |a The effect of chitosan with different molecular weights and other natural substances on dextransucrase (DSase) activity from a representative oral pathogen Streptococcus mutans was elucidated. Among other bioactive substances, amino-monosaccharides such as glucosamine, mannosamine, and galactosamine exerted the enzyme inhibitory activity over 95% of DSase. The specified hydrolysates derived from the hydrolysis of high molecular weight chitosan (HMWC) designated to CTSN, CTSN-P, CTSN-B, and CTSN-S with different molecular weights ranging from 3 to 8kDa showed the similar inhibitory activity toward DSase. Also, the hyaluronic acid (MW 8.9kDa), sulfated chitin, and amino-monosaccharides demonstrated the significant activity, CTSN, CTSN-P, CTSN-B, and CTSN-S are of potent bioactive substances that can be prepared in the cheapest way compared with other molecules tested available for antibacterial agent useful for human oral health. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Dextransucrase |2 nationallicence | |
| 690 | 7 | |a Streptococcus mutans |2 nationallicence | |
| 690 | 7 | |a Antimicrobial activity |2 nationallicence | |
| 690 | 7 | |a Oral health |2 nationallicence | |
| 690 | 7 | |a Chitosan |2 nationallicence | |
| 700 | 1 | |a Lee |D Choon |u Department of Life Sciences, Gachon University, Seongnamdaero 1342, 461-701, Seongnam-si, Gyeonggi-do, South Korea |4 aut | |
| 700 | 1 | |a Park |D Jae |u Department of Life Sciences, Gachon University, Seongnamdaero 1342, 461-701, Seongnam-si, Gyeonggi-do, South Korea |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/18(2015-09-01), 7495-7503 |x 0175-7598 |q 99:18<7495 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6693-z |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6693-z |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lee |D Choon |u Department of Life Sciences, Gachon University, Seongnamdaero 1342, 461-701, Seongnam-si, Gyeonggi-do, South Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Park |D Jae |u Department of Life Sciences, Gachon University, Seongnamdaero 1342, 461-701, Seongnam-si, Gyeonggi-do, South Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/18(2015-09-01), 7495-7503 |x 0175-7598 |q 99:18<7495 |1 2015 |2 99 |o 253 | ||