caa a22 4500 605501637 CHVBK 20210128100601.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00253-014-6310-6 doi (NATIONALLICENCE)springer-10.1007/s00253-014-6310-6 The antioxidant hydroxytyrosol: biotechnological production challenges and opportunities [Elektronische Daten] [Yigal Achmon, Ayelet Fishman] Hydroxytyrosol (HT) is a highly potent antioxidant originating in nature as a second metabolite of plants, most abundantly in olives (Olea europaea). In the last decade, numerous research studies showed the health benefits of antioxidants in general and those of HT in particular. As olive oil is a prime constituent of the health-promoting Mediterranean diet, HT has obtained recognition for its attributes, supported by a recent health claim of the European Food Safety Authority. HT is already used as a food supplement and in cosmetic products, but it has the potential to be used as a food additive and drug, based on its anticarcinogenic, anti-inflammatory, antiapoptotic and neuroprotective activity. Nevertheless, there is a large gap between the potential of HT and its current availability in the market due to its high price tag. In this review, the challenges of producing HT using biotechnological methods are described with an emphasis on the substrate source, the biocatalyst and the process parameters, in order to narrow the gap towards an efficient bio-based industrial process. Springer-Verlag Berlin Heidelberg, 2014 Hydroxytyrosol nationallicence Biocatalyst nationallicence Protein engineering nationallicence Antioxidant nationallicence Olive oil nationallicence Achmon Yigal Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, 3200003, Haifa, Israel aut Fishman Ayelet Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, 3200003, Haifa, Israel aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/3(2015-02-01), 1119-1130 0175-7598 99:3<1119 2015 99 253 https://doi.org/10.1007/s00253-014-6310-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-014-6310-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Achmon Yigal Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, 3200003, Haifa, Israel aut NATIONALLICENCE 700 1- Fishman Ayelet Department of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, 3200003, Haifa, Israel aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/3(2015-02-01), 1119-1130 0175-7598 99:3<1119 2015 99 253