Toward metabolic engineering in the context of system biology and synthetic biology: advances and prospects
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| 024 | 7 | 0 | |a 10.1007/s00253-014-6298-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-014-6298-y | ||
| 245 | 0 | 0 | |a Toward metabolic engineering in the context of system biology and synthetic biology: advances and prospects |h [Elektronische Daten] |c [Yanfeng Liu, Hyun-dong Shin, Jianghua Li, Long Liu] |
| 520 | 3 | |a Metabolic engineering facilitates the rational development of recombinant bacterial strains for metabolite overproduction. Building on enormous advances in system biology and synthetic biology, novel strategies have been established for multivariate optimization of metabolic networks in ensemble, spatial, and dynamic manners such as modular pathway engineering, compartmentalization metabolic engineering, and metabolic engineering guided by genome-scale metabolic models, in vitro reconstitution, and systems and synthetic biology. Herein, we summarize recent advances in novel metabolic engineering strategies. Combined with advancing kinetic models and synthetic biology tools, more efficient new strategies for improving cellular properties can be established and applied for industrially important biochemical production. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2014 | ||
| 690 | 7 | |a System metabolic engineering |2 nationallicence | |
| 690 | 7 | |a Modular pathway engineering |2 nationallicence | |
| 690 | 7 | |a Synthetic biology |2 nationallicence | |
| 690 | 7 | |a Genome-scale metabolic model |2 nationallicence | |
| 690 | 7 | |a Spatial engineering |2 nationallicence | |
| 700 | 1 | |a Liu |D Yanfeng |u Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China |4 aut | |
| 700 | 1 | |a Shin |D Hyun-dong |u School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 30332, Atlanta, USA |4 aut | |
| 700 | 1 | |a Li |D Jianghua |u Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China |4 aut | |
| 700 | 1 | |a Liu |D Long |u Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/3(2015-02-01), 1109-1118 |x 0175-7598 |q 99:3<1109 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-014-6298-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-014-6298-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Yanfeng |u Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shin |D Hyun-dong |u School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 30332, Atlanta, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Li |D Jianghua |u Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Long |u Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/3(2015-02-01), 1109-1118 |x 0175-7598 |q 99:3<1109 |1 2015 |2 99 |o 253 | ||