caa a22 4500 605501742 CHVBK 20210128100602.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00253-014-6298-y doi (NATIONALLICENCE)springer-10.1007/s00253-014-6298-y Toward metabolic engineering in the context of system biology and synthetic biology: advances and prospects [Elektronische Daten] [Yanfeng Liu, Hyun-dong Shin, Jianghua Li, Long Liu] Metabolic engineering facilitates the rational development of recombinant bacterial strains for metabolite overproduction. Building on enormous advances in system biology and synthetic biology, novel strategies have been established for multivariate optimization of metabolic networks in ensemble, spatial, and dynamic manners such as modular pathway engineering, compartmentalization metabolic engineering, and metabolic engineering guided by genome-scale metabolic models, in vitro reconstitution, and systems and synthetic biology. Herein, we summarize recent advances in novel metabolic engineering strategies. Combined with advancing kinetic models and synthetic biology tools, more efficient new strategies for improving cellular properties can be established and applied for industrially important biochemical production. Springer-Verlag Berlin Heidelberg, 2014 System metabolic engineering nationallicence Modular pathway engineering nationallicence Synthetic biology nationallicence Genome-scale metabolic model nationallicence Spatial engineering nationallicence Liu Yanfeng Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China aut Shin Hyun-dong School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 30332, Atlanta, USA aut Li Jianghua Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China aut Liu Long Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/3(2015-02-01), 1109-1118 0175-7598 99:3<1109 2015 99 253 https://doi.org/10.1007/s00253-014-6298-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-014-6298-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Yanfeng Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China aut NATIONALLICENCE 700 1- Shin Hyun-dong School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 30332, Atlanta, USA aut NATIONALLICENCE 700 1- Li Jianghua Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China aut NATIONALLICENCE 700 1- Liu Long Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, Jiangnan University, 214122, Wuxi, China aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/3(2015-02-01), 1109-1118 0175-7598 99:3<1109 2015 99 253