caa a22 4500 605501920 CHVBK 20210128100603.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00253-014-6271-9 doi (NATIONALLICENCE)springer-10.1007/s00253-014-6271-9 Recent research progress on microbial l -asparaginases [Elektronische Daten] [Shaohua Zuo, Tao Zhang, Bo Jiang, Wanmeng Mu] l-Asparaginases (EC 3.5.1.1) are enzymes that catalyze the hydrolysis of l-asparagine to l-aspartic acid and found in a variety of organisms from microorganisms to mammals. However, they are mainly expressed and produced by microorganisms. Microbial l-asparaginases have received sustained attention due to their irreplaceable role in the therapy of acute lymphoblastic leukemia and for their inhibition of acrylamide formation during food processing. In this article, we review the application of microbial l-asparaginases in medical treatments and acrylamide mitigation. In addition, we describe in detail recent advances in the existing sources, purification, production, properties, molecular modification, and immobilization of l-asparaginase. Springer-Verlag Berlin Heidelberg, 2014 l -Asparaginase nationallicence Acute lymphoblastic leukemia nationallicence Acrylamide nationallicence Production nationallicence Modification nationallicence Immobilization nationallicence Zuo Shaohua State Key Laboratory of Food Science and Technology, Ministry of Education Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, 214122, Wuxi, Jiangsu, China aut Zhang Tao State Key Laboratory of Food Science and Technology, Ministry of Education Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, 214122, Wuxi, Jiangsu, China aut Jiang Bo State Key Laboratory of Food Science and Technology, Ministry of Education Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, 214122, Wuxi, Jiangsu, China aut Mu Wanmeng State Key Laboratory of Food Science and Technology, Ministry of Education Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, 214122, Wuxi, Jiangsu, China aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/3(2015-02-01), 1069-1079 0175-7598 99:3<1069 2015 99 253 https://doi.org/10.1007/s00253-014-6271-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-014-6271-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zuo Shaohua State Key Laboratory of Food Science and Technology, Ministry of Education Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, 214122, Wuxi, Jiangsu, China aut NATIONALLICENCE 700 1- Zhang Tao State Key Laboratory of Food Science and Technology, Ministry of Education Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, 214122, Wuxi, Jiangsu, China aut NATIONALLICENCE 700 1- Jiang Bo State Key Laboratory of Food Science and Technology, Ministry of Education Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, 214122, Wuxi, Jiangsu, China aut NATIONALLICENCE 700 1- Mu Wanmeng State Key Laboratory of Food Science and Technology, Ministry of Education Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, 214122, Wuxi, Jiangsu, China aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/3(2015-02-01), 1069-1079 0175-7598 99:3<1069 2015 99 253