The herbal-derived honokiol and magnolol enhances immune response to infection with methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA)
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| 024 | 7 | 0 | |a 10.1007/s00253-015-6382-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6382-y | ||
| 245 | 0 | 4 | |a The herbal-derived honokiol and magnolol enhances immune response to infection with methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) |h [Elektronische Daten] |c [Eun-Jin Choi, Hyung-Ip Kim, Ji-Ae Kim, Soo Jun, Sang Kang, Dong Park, Seok-Jun Son, Younghoon Kim, Ok Shin] |
| 520 | 3 | |a The emergence of antibiotic resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) reminds us an urgent need to develop a new immune-modulating agent for preventing S. aureus infection. In this study, we found that herbal medicines, honokiol and magnolol, caused a significant cellular immune modulatory effect during S. aureus infection. In mouse macrophages, these compounds drove upregulation of an antioxidant effect in response to S. aureus, resulting in a dampened total cellular reactive oxygen species (ROS) production and decreased production of inflammatory cytokines/chemokines, whereas honokiol induced increased types I and III interferon messenger RNA (mRNA) expression levels in response to MSSA infection. Moreover, the internalization of S. aureus by human alveolar epithelial cells was inhibited by these compounds. Furthermore, honokiol and magnolol treatment promoted a delay in killing during MSSA infection in Caenorhabditis elegans, suggesting antimicrobial function in vivo. In conclusion, honokiol and magnolol may be considered as attractive immune-modulating treatment for S. aureus infection. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a S. aureus |2 nationallicence | |
| 690 | 7 | |a Herbal medicine |2 nationallicence | |
| 690 | 7 | |a Immune-modulating activity |2 nationallicence | |
| 690 | 7 | |a C. elegans |2 nationallicence | |
| 700 | 1 | |a Choi |D Eun-Jin |u Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea |4 aut | |
| 700 | 1 | |a Kim |D Hyung-Ip |u Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea |4 aut | |
| 700 | 1 | |a Kim |D Ji-Ae |u Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea |4 aut | |
| 700 | 1 | |a Jun |D Soo |u iNtRON Biotechnology, Inc., Room 903, JungAng Induspia V, 137, Sagimakgol-ro, Jungwon-gu, 462-807, Seongnam-si, Gyeonggi-do, Korea |4 aut | |
| 700 | 1 | |a Kang |D Sang |u iNtRON Biotechnology, Inc., Room 903, JungAng Induspia V, 137, Sagimakgol-ro, Jungwon-gu, 462-807, Seongnam-si, Gyeonggi-do, Korea |4 aut | |
| 700 | 1 | |a Park |D Dong |u Korea Food Research Institute, 463-746, Seongnam-si, Gyeonggi-do, Korea |4 aut | |
| 700 | 1 | |a Son |D Seok-Jun |u BK21 Plus Graduate Program, Department of Animal Science and Institute Agricultural Science & Technology, Chonbuk National University, 561-756, Jeonju, Korea |4 aut | |
| 700 | 1 | |a Kim |D Younghoon |u BK21 Plus Graduate Program, Department of Animal Science and Institute Agricultural Science & Technology, Chonbuk National University, 561-756, Jeonju, Korea |4 aut | |
| 700 | 1 | |a Shin |D Ok |u Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/10(2015-05-01), 4387-4396 |x 0175-7598 |q 99:10<4387 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6382-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6382-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Choi |D Eun-Jin |u Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Hyung-Ip |u Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Ji-Ae |u Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jun |D Soo |u iNtRON Biotechnology, Inc., Room 903, JungAng Induspia V, 137, Sagimakgol-ro, Jungwon-gu, 462-807, Seongnam-si, Gyeonggi-do, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kang |D Sang |u iNtRON Biotechnology, Inc., Room 903, JungAng Induspia V, 137, Sagimakgol-ro, Jungwon-gu, 462-807, Seongnam-si, Gyeonggi-do, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Park |D Dong |u Korea Food Research Institute, 463-746, Seongnam-si, Gyeonggi-do, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Son |D Seok-Jun |u BK21 Plus Graduate Program, Department of Animal Science and Institute Agricultural Science & Technology, Chonbuk National University, 561-756, Jeonju, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kim |D Younghoon |u BK21 Plus Graduate Program, Department of Animal Science and Institute Agricultural Science & Technology, Chonbuk National University, 561-756, Jeonju, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Shin |D Ok |u Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/10(2015-05-01), 4387-4396 |x 0175-7598 |q 99:10<4387 |1 2015 |2 99 |o 253 | ||