caa a22 4500 605502188 CHVBK 20210128100604.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00253-015-6382-y doi (NATIONALLICENCE)springer-10.1007/s00253-015-6382-y The herbal-derived honokiol and magnolol enhances immune response to infection with methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) [Elektronische Daten] [Eun-Jin Choi, Hyung-Ip Kim, Ji-Ae Kim, Soo Jun, Sang Kang, Dong Park, Seok-Jun Son, Younghoon Kim, Ok Shin] The emergence of antibiotic resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) reminds us an urgent need to develop a new immune-modulating agent for preventing S. aureus infection. In this study, we found that herbal medicines, honokiol and magnolol, caused a significant cellular immune modulatory effect during S. aureus infection. In mouse macrophages, these compounds drove upregulation of an antioxidant effect in response to S. aureus, resulting in a dampened total cellular reactive oxygen species (ROS) production and decreased production of inflammatory cytokines/chemokines, whereas honokiol induced increased types I and III interferon messenger RNA (mRNA) expression levels in response to MSSA infection. Moreover, the internalization of S. aureus by human alveolar epithelial cells was inhibited by these compounds. Furthermore, honokiol and magnolol treatment promoted a delay in killing during MSSA infection in Caenorhabditis elegans, suggesting antimicrobial function in vivo. In conclusion, honokiol and magnolol may be considered as attractive immune-modulating treatment for S. aureus infection. Springer-Verlag Berlin Heidelberg, 2015 S. aureus nationallicence Herbal medicine nationallicence Immune-modulating activity nationallicence C. elegans nationallicence Choi Eun-Jin Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea aut Kim Hyung-Ip Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea aut Kim Ji-Ae Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea aut Jun Soo iNtRON Biotechnology, Inc., Room 903, JungAng Induspia V, 137, Sagimakgol-ro, Jungwon-gu, 462-807, Seongnam-si, Gyeonggi-do, Korea aut Kang Sang iNtRON Biotechnology, Inc., Room 903, JungAng Induspia V, 137, Sagimakgol-ro, Jungwon-gu, 462-807, Seongnam-si, Gyeonggi-do, Korea aut Park Dong Korea Food Research Institute, 463-746, Seongnam-si, Gyeonggi-do, Korea aut Son Seok-Jun BK21 Plus Graduate Program, Department of Animal Science and Institute Agricultural Science & Technology, Chonbuk National University, 561-756, Jeonju, Korea aut Kim Younghoon BK21 Plus Graduate Program, Department of Animal Science and Institute Agricultural Science & Technology, Chonbuk National University, 561-756, Jeonju, Korea aut Shin Ok Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/10(2015-05-01), 4387-4396 0175-7598 99:10<4387 2015 99 253 https://doi.org/10.1007/s00253-015-6382-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6382-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Choi Eun-Jin Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Hyung-Ip Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Ji-Ae Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea aut NATIONALLICENCE 700 1- Jun Soo iNtRON Biotechnology, Inc., Room 903, JungAng Induspia V, 137, Sagimakgol-ro, Jungwon-gu, 462-807, Seongnam-si, Gyeonggi-do, Korea aut NATIONALLICENCE 700 1- Kang Sang iNtRON Biotechnology, Inc., Room 903, JungAng Induspia V, 137, Sagimakgol-ro, Jungwon-gu, 462-807, Seongnam-si, Gyeonggi-do, Korea aut NATIONALLICENCE 700 1- Park Dong Korea Food Research Institute, 463-746, Seongnam-si, Gyeonggi-do, Korea aut NATIONALLICENCE 700 1- Son Seok-Jun BK21 Plus Graduate Program, Department of Animal Science and Institute Agricultural Science & Technology, Chonbuk National University, 561-756, Jeonju, Korea aut NATIONALLICENCE 700 1- Kim Younghoon BK21 Plus Graduate Program, Department of Animal Science and Institute Agricultural Science & Technology, Chonbuk National University, 561-756, Jeonju, Korea aut NATIONALLICENCE 700 1- Shin Ok Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul, Korea aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/10(2015-05-01), 4387-4396 0175-7598 99:10<4387 2015 99 253