caa a22 4500 605502196 CHVBK 20210128100604.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00253-015-6553-x doi (NATIONALLICENCE)springer-10.1007/s00253-015-6553-x Antibacterial products of marine organisms [Elektronische Daten] [Tzi Ng, Randy Cheung, Jack Wong, Adnan Bekhit, Alaa Bekhit] Marine organisms comprising microbes, plants, invertebrates, and vertebrates elaborate an impressive array of structurally diverse antimicrobial products ranging from small cyclic compounds to macromolecules such as proteins. Some of these biomolecules originate directly from marine animals while others arise from microbes associated with the animals. It is noteworthy that some of the biomolecules referred to above are structurally unique while others belong to known classes of compounds, peptides, and proteins. Some of the antibacterial agents are more active against Gram-positive bacteria while others have higher effectiveness on Gram-negative bacteria. Some are efficacious against both Gram-positive and Gram-negative bacteria and against drug-resistant strains as well. The mechanism of antibacterial action of a large number of the chemically identified antibacterial agents, possible synergism with currently used antibiotics, and the issue of possible toxicity on mammalian cells and tissues await elucidation. The structural characteristics pivotal to antibacterial activity have been ascertained in only a few studies. Demonstration of efficacy of the antibacterial agents in animal models of bacterial infection is highly desirable. Structural characterization of the active principles present in aqueous and organic extracts of marine organisms with reportedly antibacterial activity would be desirable. Springer-Verlag Berlin Heidelberg, 2015 Antibacterial nationallicence Marine organisms nationallicence Products nationallicence Ng Tzi School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Cheung Randy School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Wong Jack School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Bekhit Adnan Faculty of Pharmacy, Alexandria University, 21521, Alexandria, Egypt aut Bekhit Alaa Department of Food Science, University of Otago, Dunedin, New Zealand aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/10(2015-05-01), 4145-4173 0175-7598 99:10<4145 2015 99 253 https://doi.org/10.1007/s00253-015-6553-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6553-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ng Tzi School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Cheung Randy School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Wong Jack School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Bekhit Adnan Faculty of Pharmacy, Alexandria University, 21521, Alexandria, Egypt aut NATIONALLICENCE 700 1- Bekhit Alaa Department of Food Science, University of Otago, Dunedin, New Zealand aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/10(2015-05-01), 4145-4173 0175-7598 99:10<4145 2015 99 253