Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase
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| 024 | 7 | 0 | |a 10.1007/s00253-015-6509-1 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6509-1 | ||
| 245 | 0 | 0 | |a Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase |h [Elektronische Daten] |c [Idalina Gonçalves, Cláudia Botelho, Ana Teixeira, Ana Abreu, Loïc Hilliou, Carla Silva, Artur Cavaco-Paulo] |
| 520 | 3 | |a Poly(hydroxybenzene)-trimethoprim conjugates were prepared using methylparaben as substrate of the oxidative enzyme tyrosinase. MALDI-TOF MS analysis showed that the enzymatic oxidation of methylparaben alone leads to the poly(hydroxybenzene) formation. In the presence of trimethoprim, the methylparaben tyrosinase oxidation leads poly(hydroxybenzene)-trimethoprim conjugates. All of these compounds were incorporated into lubricant hydroxyethyl cellulose/glycerol mixtures. Poly(hydroxybenzene)-trimethoprim conjugates were the most effective phenolic structures against the bacterial growth reducing by 96 and 97% of Escherichia coli and Staphylococcus epidermidis suspensions, respectively (after 24h). A novel enzymatic strategy to produce antimicrobial poly(hydroxybenzene)-antibiotic conjugates is proposed here for a wide range of applications on the biomedical field. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Methylparaben |2 nationallicence | |
| 690 | 7 | |a Trimethoprim |2 nationallicence | |
| 690 | 7 | |a Tyrosinase |2 nationallicence | |
| 690 | 7 | |a Poly(hydroxybenzene) |2 nationallicence | |
| 690 | 7 | |a Conjugates |2 nationallicence | |
| 690 | 7 | |a Antimicrobial |2 nationallicence | |
| 700 | 1 | |a Gonçalves |D Idalina |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | |
| 700 | 1 | |a Botelho |D Cláudia |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | |
| 700 | 1 | |a Teixeira |D Ana |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | |
| 700 | 1 | |a Abreu |D Ana |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | |
| 700 | 1 | |a Hilliou |D Loïc |u Department of Polymer Engineering, University of Minho, 4800-058, Guimarães, Portugal |4 aut | |
| 700 | 1 | |a Silva |D Carla |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | |
| 700 | 1 | |a Cavaco-Paulo |D Artur |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/10(2015-05-01), 4225-4235 |x 0175-7598 |q 99:10<4225 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6509-1 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6509-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gonçalves |D Idalina |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Botelho |D Cláudia |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Teixeira |D Ana |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Abreu |D Ana |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hilliou |D Loïc |u Department of Polymer Engineering, University of Minho, 4800-058, Guimarães, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Silva |D Carla |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cavaco-Paulo |D Artur |u CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/10(2015-05-01), 4225-4235 |x 0175-7598 |q 99:10<4225 |1 2015 |2 99 |o 253 | ||