caa a22 4500 605502773 CHVBK 20210128100607.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00253-015-6818-4 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6818-4 Antiviral activities of whey proteins [Elektronische Daten] [Tzi Ng, Randy Cheung, Jack Wong, Yan Wang, Denis Ip, David Wan, Jiang Xia] Milk contains an array of proteins with useful bioactivities. Many milk proteins encompassing native or chemically modified casein, lactoferrin, alpha-lactalbumin, and beta-lactoglobulin demonstrated antiviral activities. Casein and alpha-lactalbumin gained anti-HIV activity after modification with 3-hydroxyphthalic anhydride. Many milk proteins inhibited HIV reverse transcriptase. Bovine glycolactin, angiogenin-1, lactogenin, casein, alpha-lactalbumin, beta-lactoglobulin, bovine lactoferrampin, and human lactoferrampin inhibited HIV-1 protease and integrase. Several mammalian lactoferrins prevented hepatitis C infection. Lactoferrin, methylated alpha-lactalbumin and methylated beta-lactoglobulin inhibited human cytomegalovirus. Chemically modified alpha-lactalbumin, beta-lactoglobulin and lysozyme, lactoferrin and lactoferricin, methylated alpha-lactalbumin, methylated and ethylated beta-lactoglobulins inhibited HSV. Chemically modified bovine beta-lactoglobulin had antihuman papillomavirus activity. Beta-lactoglobulin, lactoferrin, esterified beta-lactoglobulin, and esterified lactoferrindisplayed anti-avian influenza A (H5N1) activity. Lactoferrin inhibited respiratory syncytial virus, hepatitis B virus, adenovirus, poliovirus, hantavirus, sindbis virus, semliki forest virus, echovirus, and enterovirus. Milk mucin, apolactoferrin, Fe3+-lactoferrin, beta-lactoglobulin, human lactadherin, bovine IgG, and bovine kappa-casein demonstrated antihuman rotavirus activity. Springer-Verlag Berlin Heidelberg, 2015 Whey proteins nationallicence Antiviral nationallicence Lactoferrin nationallicence Lactalbumin nationallicence Lactoglobulin nationallicence Lysozyme nationallicence Ng Tzi School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Cheung Randy School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Wong Jack School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Wang Yan School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Ip Denis School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Wan David School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut Xia Jiang Department of Chemistry, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, China aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/17(2015-09-01), 6997-7008 0175-7598 99:17<6997 2015 99 253 https://doi.org/10.1007/s00253-015-6818-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6818-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ng Tzi School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Cheung Randy School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Wong Jack School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Wang Yan School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Ip Denis School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Wan David School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Xia Jiang Department of Chemistry, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/17(2015-09-01), 6997-7008 0175-7598 99:17<6997 2015 99 253