caa a22 4500 605502846 CHVBK 20210128100607.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00253-015-6810-z doi (NATIONALLICENCE)springer-10.1007/s00253-015-6810-z Responses of Saccharomyces cerevisiae to nitrogen starvation in wine alcoholic fermentation [Elektronische Daten] [Catherine Tesnière, Claire Brice, Bruno Blondin] Nitrogen is an important nutrient in alcoholic fermentation because its starvation affects both fermentation kinetics and the formation of yeast metabolites. In most alcoholic fermentations, yeasts have to ferment in nitrogen-starved conditions, which requires modifications of cell functions to maintain a high sugar flux and enable cell survival for long periods in stressful conditions. In this review, we present an overview of our current understanding of the responses of the wine yeast Saccharomyces cerevisiae to variations of nitrogen availability. Adaptation to nitrogen starvation involves changes in the activity of signaling pathways such as target of rapamycin (TOR) and nitrogen catabolite repression (NCR), which are important for the remodeling of gene expression and the establishment of stress responses. Upon starvation, protein degradation pathways involving autophagy and the proteasome play a major role in nitrogen recycling and the adjustment of cellular activity. Recent progress in the understanding of the role of these mechanisms should enable advances in fermentation management and the design of novel targets for the selection or improvement of yeast strains. Springer-Verlag Berlin Heidelberg, 2015 Alcoholic fermentation nationallicence Nitrogen starvation nationallicence Saccharomyces cerevisiae nationallicence Wine nationallicence Tesnière Catherine INRA, UMR1083, F-34060, Montpellier, France aut Brice Claire INRA, UMR1083, F-34060, Montpellier, France aut Blondin Bruno SupAgro, UMR1083, F-34060, Montpellier, France aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/17(2015-09-01), 7025-7034 0175-7598 99:17<7025 2015 99 253 https://doi.org/10.1007/s00253-015-6810-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6810-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tesnière Catherine INRA, UMR1083, F-34060, Montpellier, France aut NATIONALLICENCE 700 1- Brice Claire INRA, UMR1083, F-34060, Montpellier, France aut NATIONALLICENCE 700 1- Blondin Bruno SupAgro, UMR1083, F-34060, Montpellier, France aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/17(2015-09-01), 7025-7034 0175-7598 99:17<7025 2015 99 253