Macroscopic modeling of mammalian cell growth and metabolism
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| 001 | 605503087 | ||
| 003 | CHVBK | ||
| 005 | 20210128100609.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150901xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00253-015-6743-6 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6743-6 | ||
| 245 | 0 | 0 | |a Macroscopic modeling of mammalian cell growth and metabolism |h [Elektronische Daten] |c [Bassem Ben Yahia, Laetitia Malphettes, Elmar Heinzle] |
| 520 | 3 | |a Abstract We review major modeling strategies and methods to understand and simulate the macroscopic behavior of mammalian cells. These strategies comprise two important steps: the first step is to identify stoichiometric relationships for the cultured cells connecting the extracellular inputs and outputs. In a second step, macroscopic kinetic models are introduced. These relationships together with bioreactor and metabolite balances provide a complete description of a system in the form of a set of differential equations. These can be used for the simulation of cell culture performance and further for optimization of production. | |
| 540 | |a The Author(s), 2015 | ||
| 690 | 7 | |a Cell culture |2 nationallicence | |
| 690 | 7 | |a Macroscopic modeling |2 nationallicence | |
| 690 | 7 | |a Antibody production |2 nationallicence | |
| 690 | 7 | |a Kinetic models |2 nationallicence | |
| 690 | 7 | |a Stoichiometric relationships |2 nationallicence | |
| 690 | 7 | |a Quality by Design |2 nationallicence | |
| 700 | 1 | |a Ben Yahia |D Bassem |u Biochemical Engineering Institute, Saarland University, Campus A1.5, D-66123, Saarbruecken, Germany |4 aut | |
| 700 | 1 | |a Malphettes |D Laetitia |u Upstream Process Sciences Biotech Sciences, UCB Pharma S.A., Avenue de l'Industrie, B-1420,, Braine l'Alleud, Belgium |4 aut | |
| 700 | 1 | |a Heinzle |D Elmar |u Biochemical Engineering Institute, Saarland University, Campus A1.5, D-66123, Saarbruecken, Germany |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/17(2015-09-01), 7009-7024 |x 0175-7598 |q 99:17<7009 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6743-6 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6743-6 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ben Yahia |D Bassem |u Biochemical Engineering Institute, Saarland University, Campus A1.5, D-66123, Saarbruecken, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Malphettes |D Laetitia |u Upstream Process Sciences Biotech Sciences, UCB Pharma S.A., Avenue de l'Industrie, B-1420,, Braine l'Alleud, Belgium |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Heinzle |D Elmar |u Biochemical Engineering Institute, Saarland University, Campus A1.5, D-66123, Saarbruecken, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/17(2015-09-01), 7009-7024 |x 0175-7598 |q 99:17<7009 |1 2015 |2 99 |o 253 | ||