caa a22 4500 605503095 CHVBK 20210128100609.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00253-015-6765-0 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6765-0 Biotransformations of organic compounds mediated by cultures of Aspergillus niger [Elektronische Daten] [Igor Parshikov, Kellie Woodling, John Sutherland] Many different organic compounds may be converted by microbial biotransformation to high-value products for the chemical and pharmaceutical industries. This review summarizes the use of strains of Aspergillus niger, a well-known filamentous fungus used in numerous biotechnological processes, for biochemical transformations of organic compounds. The substrates transformed include monocyclic, bicyclic, and polycyclic aromatic hydrocarbons; azaarenes, epoxides, chlorinated hydrocarbons, and other aliphatic and aromatic compounds. The types of reactions performed by A. niger, although not unique to this species, are extremely diverse. They include hydroxylation, oxidation of various functional groups, reduction of double bonds, demethylation, sulfation, epoxide hydrolysis, dechlorination, ring cleavage, and conjugation. Some of the products may be useful as new investigational drugs or chemical intermediates. Springer-Verlag Berlin Heidelberg (outside the USA), 2015 Arenes nationallicence Aspergillus niger nationallicence Biotransformation nationallicence Hydrocarbons nationallicence Organic compounds nationallicence Parshikov Igor Institute of Applied Mechanics, Russian Academy of Sciences, 119991, Moscow, Russia aut Woodling Kellie Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 72079, Jefferson, AR, USA aut Sutherland John Division of Microbiology, National Center for Toxicological Research, U S Food and Drug Administration, 72079, Jefferson, AR, USA aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/17(2015-09-01), 6971-6986 0175-7598 99:17<6971 2015 99 253 https://doi.org/10.1007/s00253-015-6765-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6765-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Parshikov Igor Institute of Applied Mechanics, Russian Academy of Sciences, 119991, Moscow, Russia aut NATIONALLICENCE 700 1- Woodling Kellie Division of Biochemical Toxicology, National Center for Toxicological Research, U S Food and Drug Administration, 72079, Jefferson, AR, USA aut NATIONALLICENCE 700 1- Sutherland John Division of Microbiology, National Center for Toxicological Research, U S Food and Drug Administration, 72079, Jefferson, AR, USA aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/17(2015-09-01), 6971-6986 0175-7598 99:17<6971 2015 99 253