caa a22 4500 60550329X CHVBK 20210128100610.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00253-015-6749-0 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6749-0 Survival in amoeba—a major selection pressure on the presence of bacterial copper and zinc resistance determinants? Identification of a "copper pathogenicity island” [Elektronische Daten] [Xiuli Hao, Freja Lüthje, Yanan Qin, Sylvia McDevitt, Nataliya Lutay, Jon Hobman, Karishma Asiani, Fernando Soncini, Nadezhda German, Siyu Zhang, Yong-Guan Zhu, Christopher Rensing] The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture. While this is certainly true, we hypothesize that protozoan predation and macrophage killing are also responsible for selection of copper/zinc resistance genes in bacteria. In this review, we outline evidence supporting this hypothesis, as well as highlight the correlation between metal resistance and pathogenicity in bacteria. In addition, we introduce and characterize the "copper pathogenicity island” identified in Escherichia coli and Salmonella strains isolated from copper- and zinc-fed Danish pigs. Springer-Verlag Berlin Heidelberg, 2015 Copper nationallicence Pathogenicity nationallicence Amoeba nationallicence Grazing resistance nationallicence Hao Xiuli Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, People's Republic of China aut Lüthje Freja Department of Plant and Environmental Science, University of Copenhagen, 1871, Frederiksberg, Denmark aut Qin Yanan Department of Plant and Environmental Science, University of Copenhagen, 1871, Frederiksberg, Denmark aut McDevitt Sylvia Department of Biology, Skidmore College, Saratoga Springs, NY, USA aut Lutay Nataliya Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Lund, Sweden aut Hobman Jon School of Biosciences, The University of Nottingham, Sutton Bonington Campus, LE12 5RD, Sutton Bonington, UK aut Asiani Karishma School of Biosciences, The University of Nottingham, Sutton Bonington Campus, LE12 5RD, Sutton Bonington, UK aut Soncini Fernando Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET, UNR), 2000, Rosario, Argentina aut German Nadezhda Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas aut Zhang Siyu Department of Plant and Environmental Science, University of Copenhagen, 1871, Frederiksberg, Denmark aut Zhu Yong-Guan Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, People's Republic of China aut Rensing Christopher Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, People's Republic of China aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/14(2015-07-01), 5817-5824 0175-7598 99:14<5817 2015 99 253 https://doi.org/10.1007/s00253-015-6749-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6749-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hao Xiuli Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, People's Republic of China aut NATIONALLICENCE 700 1- Lüthje Freja Department of Plant and Environmental Science, University of Copenhagen, 1871, Frederiksberg, Denmark aut NATIONALLICENCE 700 1- Qin Yanan Department of Plant and Environmental Science, University of Copenhagen, 1871, Frederiksberg, Denmark aut NATIONALLICENCE 700 1- McDevitt Sylvia Department of Biology, Skidmore College, Saratoga Springs, NY, USA aut NATIONALLICENCE 700 1- Lutay Nataliya Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Lund, Sweden aut NATIONALLICENCE 700 1- Hobman Jon School of Biosciences, The University of Nottingham, Sutton Bonington Campus, LE12 5RD, Sutton Bonington, UK aut NATIONALLICENCE 700 1- Asiani Karishma School of Biosciences, The University of Nottingham, Sutton Bonington Campus, LE12 5RD, Sutton Bonington, UK aut NATIONALLICENCE 700 1- Soncini Fernando Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET, UNR), 2000, Rosario, Argentina aut NATIONALLICENCE 700 1- German Nadezhda Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas aut NATIONALLICENCE 700 1- Zhang Siyu Department of Plant and Environmental Science, University of Copenhagen, 1871, Frederiksberg, Denmark aut NATIONALLICENCE 700 1- Zhu Yong-Guan Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, People's Republic of China aut NATIONALLICENCE 700 1- Rensing Christopher Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, People's Republic of China aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/14(2015-07-01), 5817-5824 0175-7598 99:14<5817 2015 99 253