caa a22 4500 605503680 CHVBK 20210128100612.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00253-014-6350-y doi (NATIONALLICENCE)springer-10.1007/s00253-014-6350-y Recent applications of Vitreoscilla hemoglobin technology in bioproduct synthesis and bioremediation [Elektronische Daten] [Benjamin Stark, Krishna Pagilla, Kanak Dikshit] Since its first use in 1990 to enhance production of α-amylase in E. coli, engineering of heterologous hosts to express the hemoglobin from the bacterium Vitreoscilla (VHb) has become a widely used strategy to enhance production of a variety of bioproducts, stimulate bioremediation, and increase growth and survival of engineered organisms. The hosts have included a variety of bacteria, yeast, fungi, higher plants, and even animals. The beneficial effects of VHb expression are presumably the result of one or more of its activities. The available evidence indicates that these include oxygen binding and delivery to the respiratory chain and oxygenases, protection against reactive oxygen species, and control of gene expression. In the past 4 to 5years, the use of this "VHb technology” has continued in a variety of biotechnological applications in a wide range of organisms. These include enhancement of production of an ever wider array of bioproducts, new applications in bioremediation, a possible role in enhancing aerobic waste water treatment, and the potential to enhance growth and survival of both plants and animals of economic importance. Springer-Verlag Berlin Heidelberg, 2015 Bioproducts nationallicence Bioremediation nationallicence Genetic engineering nationallicence Vitreoscilla hemoglobin nationallicence Waste water nationallicence Stark Benjamin Biology Division, Department of Biological and Chemical Sciences, Illinois Institute of Technology, 60616, Chicago, IL, USA aut Pagilla Krishna Department of Civil, Architectural, and Environmental Engineering, Illinois Institute of Technology, 60616, Chicago, IL, USA aut Dikshit Kanak Institute of Microbial Technology, Sec-39a, 160036, Chandigarh, India aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/4(2015-02-01), 1627-1636 0175-7598 99:4<1627 2015 99 253 https://doi.org/10.1007/s00253-014-6350-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-014-6350-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stark Benjamin Biology Division, Department of Biological and Chemical Sciences, Illinois Institute of Technology, 60616, Chicago, IL, USA aut NATIONALLICENCE 700 1- Pagilla Krishna Department of Civil, Architectural, and Environmental Engineering, Illinois Institute of Technology, 60616, Chicago, IL, USA aut NATIONALLICENCE 700 1- Dikshit Kanak Institute of Microbial Technology, Sec-39a, 160036, Chandigarh, India aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/4(2015-02-01), 1627-1636 0175-7598 99:4<1627 2015 99 253