Biotransformation of artemisinin by Aspergillus niger
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| 024 | 7 | 0 | |a 10.1007/s00253-015-6464-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6464-x | ||
| 245 | 0 | 0 | |a Biotransformation of artemisinin by Aspergillus niger |h [Elektronische Daten] |c [Yulian Zhan, Hua Liu, Yunshan Wu, Pingying Wei, Zhencheng Chen, John Williamson] |
| 520 | 3 | |a Biotransformation of artemisinin (1) by Aspergillus niger was investigated. During 12days at 28°C and pH 6.0, A. niger transformed artemisinin into four products. They were identified as 3β-hydroxy-4,12-epoxy-1-deoxyartemisinin (2), artemisinin G (3), 3,13-epoxyartemisinin (4), and 4α-hydroxy-1-deoxyartemisinin (5). Products 2 and 4 are new compounds and are being reported here for the first time. The product 4 contains a 3,13-epoxy structure. This is the first report of epoxidation of artemisinin using microbial strains. The product 4 still has an intact peroxide bridge and therefore can be used as a scaffold for further structural modification using chemical and biological methods in the search for new antimalarial drugs. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Biotransformation |2 nationallicence | |
| 690 | 7 | |a Artemisinin |2 nationallicence | |
| 690 | 7 | |a Antimalarial drugs |2 nationallicence | |
| 690 | 7 | |a Aspergillus niger |2 nationallicence | |
| 700 | 1 | |a Zhan |D Yulian |u School of Life and Environmental Sciences, Guilin University of Electronic Technology, 541004, Guilin, People's Republic of China |4 aut | |
| 700 | 1 | |a Liu |D Hua |u Department of Medicinal Chemistry, University of Mississippi, 38677-1848, University, MS, USA |4 aut | |
| 700 | 1 | |a Wu |D Yunshan |u Department of Medicinal Chemistry, University of Mississippi, 38677-1848, University, MS, USA |4 aut | |
| 700 | 1 | |a Wei |D Pingying |u School of Life and Environmental Sciences, Guilin University of Electronic Technology, 541004, Guilin, People's Republic of China |4 aut | |
| 700 | 1 | |a Chen |D Zhencheng |u School of Life and Environmental Sciences, Guilin University of Electronic Technology, 541004, Guilin, People's Republic of China |4 aut | |
| 700 | 1 | |a Williamson |D John |u Department of Medicinal Chemistry, University of Mississippi, 38677-1848, University, MS, USA |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/8(2015-04-01), 3443-3446 |x 0175-7598 |q 99:8<3443 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6464-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6464-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zhan |D Yulian |u School of Life and Environmental Sciences, Guilin University of Electronic Technology, 541004, Guilin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Liu |D Hua |u Department of Medicinal Chemistry, University of Mississippi, 38677-1848, University, MS, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wu |D Yunshan |u Department of Medicinal Chemistry, University of Mississippi, 38677-1848, University, MS, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wei |D Pingying |u School of Life and Environmental Sciences, Guilin University of Electronic Technology, 541004, Guilin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chen |D Zhencheng |u School of Life and Environmental Sciences, Guilin University of Electronic Technology, 541004, Guilin, People's Republic of China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Williamson |D John |u Department of Medicinal Chemistry, University of Mississippi, 38677-1848, University, MS, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/8(2015-04-01), 3443-3446 |x 0175-7598 |q 99:8<3443 |1 2015 |2 99 |o 253 | ||