caa a22 4500 605504180 CHVBK 20210128100614.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00253-015-6508-2 doi (NATIONALLICENCE)springer-10.1007/s00253-015-6508-2 A giant market and a powerful metabolism: l -lysine provided by Corynebacterium glutamicum [Elektronische Daten] [Lothar Eggeling, Michael Bott] l-lysine is made in an exceptional large quantity of currently 2,200,000tons/year and belongs therefore to one of the leading biotechnological products. Production is done almost exclusively with mutants of Corynebacterium glutamicum. The increasing l-lysine market forces companies to improve the production process fostering also a deeper understanding of the microbial physiology of C. glutamicum. Current major challenges are the identification of ancillary mutations not intuitively related with product increase. This review gives insights on how cellular characteristics enable to push the carbon flux in metabolism towards its theoretical maximum, and this example may also serve as a guide to achieve and increase the formation of other products of interest in microbial biotechnology. Springer-Verlag Berlin Heidelberg, 2015 Central metabolism nationallicence Non-intuitive mutations nationallicence Reducing power nationallicence Metabolite production nationallicence FACS screenings nationallicence Eggeling Lothar IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülich, 52458, Jülich, Germany aut Bott Michael IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülich, 52458, Jülich, Germany aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/8(2015-04-01), 3387-3394 0175-7598 99:8<3387 2015 99 253 https://doi.org/10.1007/s00253-015-6508-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6508-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Eggeling Lothar IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülich, 52458, Jülich, Germany aut NATIONALLICENCE 700 1- Bott Michael IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülich, 52458, Jülich, Germany aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/8(2015-04-01), 3387-3394 0175-7598 99:8<3387 2015 99 253