Antimicrobial peptides: an alternative for innovative medicines?
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| 024 | 7 | 0 | |a 10.1007/s00253-015-6375-x |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00253-015-6375-x | ||
| 245 | 0 | 0 | |a Antimicrobial peptides: an alternative for innovative medicines? |h [Elektronische Daten] |c [João da Costa, Marta Cova, Rita Ferreira, Rui Vitorino] |
| 520 | 3 | |a Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi, viruses, bacteria, and even tumor cells that make these molecules attractive as therapeutic agents. Due to the alarming increase of antimicrobial resistance, interest in alternative antimicrobial agents has led to the exploitation of antimicrobial peptides, both synthetic and from natural sources. Thus, many peptide-based drugs are currently commercially available for the treatment of numerous ailments, such as hepatitis C, myeloma, skin infections, and diabetes. Initial barriers are being increasingly overcome with the development of cost-effective, more stable peptides. Herein, we review the available strategies for their synthesis, bioinformatics tools for the rational design of antimicrobial peptides with enhanced therapeutic indices, hurdles and shortcomings limiting the large-scale production of AMPs, as well as the challenges that the pharmaceutical industry faces on their use as therapeutic agents. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Salivary peptide |2 nationallicence | |
| 690 | 7 | |a Antitumoral |2 nationallicence | |
| 690 | 7 | |a Synthesis |2 nationallicence | |
| 690 | 7 | |a Bioinformatics |2 nationallicence | |
| 700 | 1 | |a da Costa |D João |u Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal |4 aut | |
| 700 | 1 | |a Cova |D Marta |u Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal |4 aut | |
| 700 | 1 | |a Ferreira |D Rita |u Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal |4 aut | |
| 700 | 1 | |a Vitorino |D Rui |u Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal |4 aut | |
| 773 | 0 | |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/5(2015-03-01), 2023-2040 |x 0175-7598 |q 99:5<2023 |1 2015 |2 99 |o 253 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00253-015-6375-x |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00253-015-6375-x |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a da Costa |D João |u Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Cova |D Marta |u Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ferreira |D Rita |u Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vitorino |D Rui |u Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Applied Microbiology and Biotechnology |d Springer Berlin Heidelberg |g 99/5(2015-03-01), 2023-2040 |x 0175-7598 |q 99:5<2023 |1 2015 |2 99 |o 253 | ||