caa a22 4500 605504253 CHVBK 20210128100615.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00253-015-6375-x doi (NATIONALLICENCE)springer-10.1007/s00253-015-6375-x Antimicrobial peptides: an alternative for innovative medicines? [Elektronische Daten] [João da Costa, Marta Cova, Rita Ferreira, Rui Vitorino] Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi, viruses, bacteria, and even tumor cells that make these molecules attractive as therapeutic agents. Due to the alarming increase of antimicrobial resistance, interest in alternative antimicrobial agents has led to the exploitation of antimicrobial peptides, both synthetic and from natural sources. Thus, many peptide-based drugs are currently commercially available for the treatment of numerous ailments, such as hepatitis C, myeloma, skin infections, and diabetes. Initial barriers are being increasingly overcome with the development of cost-effective, more stable peptides. Herein, we review the available strategies for their synthesis, bioinformatics tools for the rational design of antimicrobial peptides with enhanced therapeutic indices, hurdles and shortcomings limiting the large-scale production of AMPs, as well as the challenges that the pharmaceutical industry faces on their use as therapeutic agents. Springer-Verlag Berlin Heidelberg, 2015 Salivary peptide nationallicence Antitumoral nationallicence Synthesis nationallicence Bioinformatics nationallicence da Costa João Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal aut Cova Marta Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal aut Ferreira Rita Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal aut Vitorino Rui Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal aut Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/5(2015-03-01), 2023-2040 0175-7598 99:5<2023 2015 99 253 https://doi.org/10.1007/s00253-015-6375-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00253-015-6375-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- da Costa João Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal aut NATIONALLICENCE 700 1- Cova Marta Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal aut NATIONALLICENCE 700 1- Ferreira Rita Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal aut NATIONALLICENCE 700 1- Vitorino Rui Mass Spectrometry Centre, QOPNA, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer Berlin Heidelberg 99/5(2015-03-01), 2023-2040 0175-7598 99:5<2023 2015 99 253